Evidence map›Paper›PMID 32140387›Full record

ReviewActa pharmaceutica Sinica. B2020

Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1.

Chang Yan, Zhuo Luo, Wen Li, Xue Li, Robert Dallmann, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 92 citations in OpenAlex.

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  13. "Biomaterials translational · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Chang YanGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.
Zhuo LuoGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.
Wen LiGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.
Xue LiInstitute of Atmospheric Environmental Safety and Pollution Control, Jinan University, Guangzhou 510632, China.
Robert DallmannWarwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
Hiroshi KuriharaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.
Yi-Fang LiGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.
Rong-Rong HeGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.
Jinan University · CNUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral tissues

Indexed as

4E-BP, eIF4E-binding proteinAD, Alzheimer's diseaseAKT, protein kinase BAMPK, AMP-dependent kinaseBCL-2, B-cell lymphoma 2cGAS, cyclic GMP-AMP synthaseCNS, central nervous systemCoREST, REST corepressor 1CORT, corticosteroneCPE, cytopathic effectCTCF, CCCTC-binding factorCTL, cytotoxic T lymphocyteDAMPs, damage-associated molecular patternsDCs, dendritic cellsDEX, dexamethasoneGREs, GR response elementsGRs, glucocorticoid receptorsH3K9, histone H3 on lysines 9HCF-1, host cell factor 1HDACs, histone deacetylasesHerpes simplex virus type 1HPA axis, hypothalamo–pituitary–adrenal axisHPK, herpetic simplex keratitisHPT axis, hypothalamic–pituitary–thyroid axisHSV-1HSV-1, herpes simplex virus type 1ICP, infected cell polypeptideIRF3, interferon regulatory factor 3KLF15, Krüppel-like transcription factor 15LatencyLAT, latency-associated transcriptsLRF, Luman/CREB3 recruitment factorLSD1, lysine-specific demethylase 1MAVS, mitochondrial antiviral-signaling proteinMOI, multiplicity of infectionmTOR, mammalian target of rapamycinND10, nuclear domains 10NGF, nerve growth factorNK cells, natural killer cellsOCT-1, octamer binding protein 1ORFs, open reading framesPAMPs, pathogen-associated molecular patternsPDK1, pyruvate dehydrogenase lipoamide kinase isozyme 1PI3K, phosphoinositide 3-kinasesPML, promyelocytic leukemia proteinPNS, peripheral nervous systemPRC1, protein regulator of cytokinesis 1PRRs, pattern-recognition receptorsPTMs, post-translational modificationsRANKL, receptor activator of NF-κB ligandsReactivationREST, RE1-silencing transcription factorROS, reactive oxygen speciesSGKs, serum and glucocorticoid-regulated protein kinasesSIRT1, sirtuin 1sncRNAs, small non-coding RNAsStressSusceptibilityT3, thyroid hormoneTCM, traditional Chinese medicineTG, trigeminal gangliaTK, thymidine kinaseTRIM14, tripartite motif-containing 14TRKA, tropomyosin receptor kinase ATRM, tissue resident memory T cells

Identifiers

PMID32140387
PMCPMC7049575
OpenAlexW2951779645

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.