Evidence map›Paper›PMID 32140865›Full record

ReviewJournal of neurology2021

Axonal variants of Guillain-Barré syndrome: an update.

Pei Shang, Mingqin Zhu, Ying Wang, Xiangyu Zheng, Xiujuan Wu, Jie Zhu, Jiachun Feng, Hong-Liang Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Triggers of Guillain-Barré Syndrome:International journal of molecular sciences · 2022
    Pooled it
  3. Pooled it
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  12. [Epidemiological and clinical aspects of Guilain-Barré syndrome, 2012-2022].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Pei ShangDepartment of Neurology, First Hospital of Jilin University, Xinmin Street 71#, Changchun, 130021, China.ORCID http://orcid.org/0000-0003-4345-2165
Mingqin ZhuDepartment of Neurology, First Hospital of Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Ying WangDepartment of Neurology, First Hospital of Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Xiangyu ZhengDepartment of Neurology, First Hospital of Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Xiujuan WuDepartment of Neurology, First Hospital of Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Jie ZhuDepartment of Neurology, First Hospital of Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Jiachun FengDepartment of Neurology, First Hospital of Jilin University, Xinmin Street 71#, Changchun, 130021, China. fengjcfrank@qq.com.ORCID http://orcid.org/0000-0003-4845-424X
Hong-Liang ZhangDepartment of Life Sciences, National Natural Science Foundation of China, Shuangqing Road 83#, Beijing, 100085, China. drzhl@hotmail.com.ORCID http://orcid.org/0000-0001-9205-5559
Jilin University · CNNational Natural Science Foundation of China · CN

Funding

National Key R&D Program of China No. 2017YFC0110304National Natural Science Foundation of China No. 31600820National Natural Science Foundation of China No. 81771257
6 · The paper itself

Abstract

Axonal variants of Guillain-Barré syndrome (GBS) mainly include acute motor axonal neuropathy, acute motor and sensory axonal neuropathy, and pharyngeal-cervical-brachial weakness. Molecular mimicry of human gangliosides by a pathogen's lipooligosaccharides is a well-established mechanism for Campylobacter jejuni-associated GBS. New triggers of the axonal variants of GBS (axonal GBS), such as Zika virus, hepatitis viruses, intravenous administration of ganglioside, vaccination, and surgery, are being identified. However, the pathogenetic mechanisms of axonal GBS related to antecedent bacterial or viral infections other than Campylobacter jejuni remain unknown. Currently, autoantibody classification and serial electrophysiology are cardinal approaches to differentiate axonal GBS from the prototype of GBS, acute inflammatory demyelinating polyneuropathy. Newly developed technologies, including metabolite analysis, peripheral nerve ultrasound, and feature selection via artificial intelligence are facilitating more accurate diagnosis of axonal GBS. Nevertheless, some key issues, such as genetic susceptibilities, remain unanswered and moreover, current therapies bear limitations. Although several therapies have shown considerable benefits to experimental animals, randomized controlled trials are still needed to validate their efficacy.

Indexed as

Campylobacter InfectionsCampylobacter jejuniGuillain-Barre SyndromeZika VirusZika Virus InfectionAnimalsArtificial IntelligenceAutoantibodiesGangliosidesHumansAutoantibodiesGangliosidesAcute motor and sensory axonal neuropathyAcute motor axonal neuropathyAxonal GBSGuillain–Barré syndrome

Identifiers

PMID32140865
OpenAlexW3009574719

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.