Evidence map›Paper›PMID 32144132›Full record

ArticleGenetics2020

Rif1 Functions in a Tissue-Specific Manner To Control Replication Timing Through Its PP1-Binding Motif.

Robin L Armstrong, Souradip Das, Christina A Hill, Robert J Duronio, Jared T Nordman

Open access · hybridAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Genes & development · 2024
    Article
  4. Article
  5. Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Robin L Armstrong *Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599.ORCID 0000-0003-0018-4068
Souradip Das *Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232.ORCID 0000-0002-8427-7749
Christina A HillIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599.
Robert J DuronioCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599 duronio@med.unc.edu jared.nordman@vanderbilt.edu.ORCID 0000-0001-6469-6965
Jared T NordmanDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232 duronio@med.unc.edu jared.nordman@vanderbilt.edu.ORCID 0000-0002-6612-3201
University of North Carolina at Chapel Hill · USVanderbilt University · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Regulation of Metazoan DNA Replication by ChromatinR01GM124201 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J · 2018 to 2021
$1.2M
NCI NIH HHS P30 CA016086NCI NIH HHS P30 CA068485NIDDK NIH HHS P30 DK058404NIGMS NIH HHS R01 GM124201NIGMS NIH HHS T32 GM007092
6 · The paper itself

Abstract

Replication initiation in eukaryotic cells occurs asynchronously throughout S phase, yielding early- and late-replicating regions of the genome, a process known as replication timing (RT). RT changes during development to ensure accurate genome duplication and maintain genome stability. To understand the relative contributions that cell lineage, cell cycle, and replication initiation regulators have on RT, we utilized the powerful developmental systems available in

Indexed as

DNA Replication TimingAnimalsBinding SitesCarrier ProteinsCell LineageDrosophila melanogasterDrosophila ProteinsFemaleImaginal DiscsMitosisOrgan SpecificityOvaryProtein BindingProtein Phosphatase 1Carrier ProteinsDrosophila ProteinsProtein Phosphatase 1Rif1 protein, DrosophilaDNA replicationDrosophilaendocyclegenome integrityreplication timingRif1

Identifiers

PMID32144132
PMCPMC7198277
OpenAlexW3010434909

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.