ArticleJournal of psychiatric research2020
A novel method of evaluating semantic intrusion errors to distinguish between amyloid positive and negative groups on the Alzheimer's disease continuum.
Article in Journal of psychiatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Cognitive dysfunction in women with theJournal of Alzheimer's disease : JAD · 2026Article
- Semantic Intrusion Errors Overcome the Impact of Literacy and Educational Attainment in Black/African Americans with and without Mild Cognitive Impairment.Advances in Alzheimer's disease · 2025Article
- Development and comparison of alternate forms of the Loewenstein-Acevedo Scales for Semantic Interference and Learning-Digital Version (LASSI-D) in older participants with amnestic mild cognitive impairment and normal cognition.Journal of Alzheimer's disease : JAD · 2025Article
- Detecting Cognitive Impairment in African American Older Adults Using the LASSI-L and Plasma P-TauAdvances in Alzheimer's disease · 2025Article
- Failure to recover from proactive semantic interference predicts trajectory of decline in everyday function among older adults with amnestic mild cognitive impairment.International psychogeriatrics · 2025Article
- Digital Migration of the Loewenstein Acevedo Scales for Semantic Interference and Learning (LASSI-L): Development and Validation Study in Older Participants.JMIR mental health · 2025Article
- Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tauFrontiers in neurology · 2025Article
- The computerized LASSI-BC Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-Based-Samples.Advances in Alzheimer's disease · 2024Article
- The Association Between Plasma Amyloid-β 42/40 and Percentage of Semantic Intrusion Errors in Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2024Article
- Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia.Frontiers in aging neuroscience · 2024Article
- A review of novel Cognitive Challenge Tests for the assessment of preclinical Alzheimer's disease.Neuropsychology · 2023Review
- A Novel Computerized Cognitive Test for the Detection of Mild Cognitive Impairment and Its Association with Neurodegeneration in Alzheimer's Disease Prone Brain Regions.Advances in Alzheimer's disease · 2023Article
- Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive.Frontiers in neurology · 2023Article
- Semantic intrusion errors as a function of age, amyloid, and volumetric loss: a confirmatory path analysis.International psychogeriatrics · 2022Article
- Salient Cognitive Paradigms to Assess Preclinical Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Persistent Failure to Recover from Proactive Semantic Interference on the Cognitive Stress Test Differentiates Between Amnestic Mild Cognitive Impairment, Pre-Mild Cognitive Impairment, and Cognitively Unimpaired Older Adults.Journal of Alzheimer's disease : JAD · 2022Article
- Amnestic Mild Cognitive Impairment is Characterized by the Inability to Recover from Proactive Semantic Interference across Multiple Learning Trials.The journal of prevention of Alzheimer's disease · 2021Article
- The relationship of semantic intrusions to different etiological subtypes of MCI and cognitively healthy older adults.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline.Frontiers in aging neuroscience · 2021Article
- A Spanish Neuropsychological Battery Discriminates Between the Behavioral Variant of Frontotemporal Dementia and Primary Progressive Aphasia in a Colombian Sample.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe development and validation of clinical outcome measures to detect early cognitive decline associated with Alzheimer's disease (AD) biomarkers is imperative. Semantic intrusions on the Loewenstein Acevedo Scales of Semantic Interference and Learning (LASSI-L) has outperformed widely used cognitive measures as an early correlate of elevated brain amyloid in prodromal AD and has distinguished those with amnestic mild cognitive impairment (aMCI) and high amyloid load from aMCI attributable to other non-AD conditions.
methodsSince intrusion errors on memory tasks vary widely, we employed a novel method that accounts for the percentage of intrusion errors (PIE) in relation to total responses. Individuals with either high or low amyloid load across the spectrum of aMCI and dementia and amyloid negative cognitively normal older adults (CN) were studied.
resultsMean PIE on indices sensitive to proactive semantic interference (PSI) and failure to recover from proactive semantic interference (frPSI) could distinguish amyloid positive from amyloid negative aMCI and dementia groups. Number of correct responses alone, while able to differentiate the different diagnostic groups, did not differentiate amyloid positive aMCI from their counterparts without amyloid pathology.
conclusionsPIE, a novel and sensitive index of early memory dysfunction, demonstrated high levels of sensitivity and specificity in differentiating CN from amyloid positive persons with preclinical AD. Mean levels of PIE are higher for amyloid positive aMCI and dementia participants relative to their amyloid negative counterparts.
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