Evidence map›Paper›PMID 32147018›Full record

ReviewNeurosurgery clinics of North America2020

New Prospects for Molecular Targets for Chordomas.

Mohammad Zeeshan Ozair, Pavan Pinkesh Shah, Dimitrios Mathios, Michael Lim, Nelson S Moss

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurosurgery clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Mohammad Zeeshan OzairLaboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Pavan Pinkesh ShahDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21287, USA.
Dimitrios MathiosDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21287, USA.
Michael LimDepartment of Neurosurgery, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21287, USA.
Nelson S MossDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: mossn@mskcc.org.
Johns Hopkins Medicine · USJohns Hopkins University · USMemorial Sloan Kettering Cancer Center · USRockefeller University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
A new approach to biological recording of lineage hierarchy in primate brainsRF1MH120026 · NIMH · ROCKEFELLER UNIVERSITY · PI BRIVANLOU, ALI H · 2019 to 2019
$1.2M
NCI NIH HHS P30 CA008748NIMH NIH HHS RF1 MH120026
6 · The paper itself

Abstract

Chordomas are malignant, highly recurrent tumors of the midline skeleton that arise from the remnants of the notochord. The development of systemic therapy is critically important to ultimately managing this tumor. Several ongoing trials are attempting to use molecular targeted therapies for mutated pathways in recurrent and advanced chordomas and have shown promise. In addition, immunotherapies, including brachyury-directed vaccination and checkpoint inhibition, have also been attempted with encouraging results. This article discusses the major pathways that have been implicated in the pathogenesis of chordoma with an emphasis on molecular vulnerabilities that future therapies are attempting to exploit.

Indexed as

Bone and BonesBrachyury ProteinChordomaFetal ProteinsHumansNeoplasm Recurrence, LocalNotochordT-Box Domain ProteinsBrachyury ProteinFetal ProteinsT-Box Domain ProteinsBrachyuryChordomaImmunotherapyMolecular targeted therapyNotochordReceptor tyrosine kinase (RTKs)

Identifiers

PMID32147018
PMCPMC7374924
OpenAlexW3000797409

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.