Evidence map›Paper›PMID 32148123›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Cardiovascular Regulation by the Neuronal BBSome.

Deng-Fu Guo, John J Reho, Donald A Morgan, Kamal Rahmouni

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Adipocyte-specific disruption of the BBSome causes metabolic and autonomic dysfunction.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  4. Metabolic consequences of skeletal muscle- and liver-specific BBSome deficiency.American journal of physiology. Endocrinology and metabolism · 2023
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Deng-Fu GuoFrom the Department of Neuroscience and Pharmacology (D.-F.G., J.J.R., D.A.M., K.R.), University of Iowa Carver College of Medicine, Iowa City.
John J RehoFrom the Department of Neuroscience and Pharmacology (D.-F.G., J.J.R., D.A.M., K.R.), University of Iowa Carver College of Medicine, Iowa City.
Donald A MorganFrom the Department of Neuroscience and Pharmacology (D.-F.G., J.J.R., D.A.M., K.R.), University of Iowa Carver College of Medicine, Iowa City.
Kamal RahmouniFrom the Department of Neuroscience and Pharmacology (D.-F.G., J.J.R., D.A.M., K.R.), University of Iowa Carver College of Medicine, Iowa City.
University of Iowa · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
Neuronal Mechanisms of Obesity-Induced HypertensionI01BX004249 · VA · IOWA CITY VA MEDICAL CENTER · PI KAMAL RAHMOUNI · 2019 to 2026
–
BLRD VA I01 BX004249NHLBI NIH HHS P01 HL084207
6 · The paper itself

Abstract

The BBSome, a complex of 8 BBS (Bardet-Biedl syndrome) proteins known for its role in the control of cilia function and other cellular processes, has been implicated in blood pressure control, but the underlying mechanisms are not fully understood. Here, we show that neuronal BBSome plays an important role in blood pressure regulation. Targeted inactivation of the BBSome in the nervous system through

Indexed as

AnimalsBardet-Biedl SyndromeBlood PressureCytoskeletal ProteinsHeart RateMiceMice, KnockoutNeuronsPro-OpiomelanocortinProtein TransportReceptors, LeptinSympathetic Nervous SystemCytoskeletal ProteinsPro-OpiomelanocortinReceptors, LeptinBardet-Biedl syndromeblood pressurebrainciliasympathetic nervous system

Identifiers

PMID32148123
PMCPMC7101031
OpenAlexW3011359459

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.