ArticleInvestigative ophthalmology & visual science2020
Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Current Trends in AI and Eye Disease Diagnostics.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Review
- Effect of Korean red ginseng on deep capillary plexus parameters in diabetic retinopathy: A prospective, randomized, double-blind clinical trial.Journal of ginseng research · 2026Article
- Early retinal, optic disc and choriocapillaris microvascular alterations in children with type 1 diabetes without clinical retinopathy: an OCTA-based case-control study.BMC ophthalmology · 2026Article
- Postprandial C-Peptide to Glucose Ratio as a Promising Systemic Marker of Diabetic Retinopathy in Type 2 Diabetes.Translational vision science & technology · 2025Article
- Effect of disease duration on foveal microvasculature assessed by OCTA in type 2 diabetes mellitus without clinical diabetic retinopathy.International journal of retina and vitreous · 2025Article
- Effect of panretinal photocoagulation versus intravitreal bevacizumab injection on optic disc microcirculation in patients with diabetic retinopathy.International journal of retina and vitreous · 2024Article
- Severity Stratification of Coronary Artery Disease Using Novel Inner Ellipse-Based Foveal Avascular Zone Biomarkers.Investigative ophthalmology & visual science · 2024Article
- Unlocking the Potential of Vessel Density and the Foveal Avascular Zone in Optical Coherence Tomography Angiography as Biomarkers in Alzheimer's Disease.Healthcare (Basel, Switzerland) · 2024Review
- Retinal Microvascular Alterations in Hidradenitis Suppurativa Patients: A Pilot Study Using Optical Coherence Tomography Angiography.Journal of clinical medicine · 2024Article
- An Investigation of the Correlation Between Retinal Nerve Fiber Layer Thickness with Blood Biochemical Indices and Cognitive Dysfunction in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Insulin resistance in the retina: possible implications for certain ocular diseases.Frontiers in endocrinology · 2024Review
- Vascular abnormalities in fellow eyes of patients with unilateral coats' disease.Scientific reports · 2023Article
- Pre-Ophthalmoscopic Quantitative Biomarkers in Diabetes Mellitus.Translational vision science & technology · 2023Article
- Central and peripheral changes in the retina and choroid in patients with diabetes mellitus without clinical diabetic retinopathy assessed by ultra-wide-field optical coherence tomography angiography.Frontiers in public health · 2023Article
- Application of ImageJ in Optical Coherence Tomography Angiography (OCT-A): A Literature Review.Journal of ophthalmology · 2023Review
- Compensatory contribution of retinal larger vessels to perfusion density in diabetics without retinopathy.Scientific reports · 2022Article
- Using optical coherence tomography angiography as a biomarker of retinopathy severity and treatment for diabetic retinopathy.Molecular vision · 2022Article
- Retinal Vascular Response to Hyperoxia in Patients with Diabetes Mellitus without Diabetic Retinopathy.Journal of ophthalmology · 2021Article
- Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography.Frontiers in aging neuroscience · 2021Article
- Effects of Induced Astigmatism on Spectral Domain-OCT Angiography Quantitative Metrics.American journal of ophthalmology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Purpose: To investigate the clinical significance of the changes in the macular microvasculature in patients with diabetes mellitus type 2 without diabetic retinopathy. Methods: Fifty-five patients with diabetes mellitus type 2 without diabetic retinopathy and 48 healthy individuals were enrolled in a prospective cross-sectional study. We identified the changes of optical coherence tomography angiography parameters (foveal avascular zone [FAZ] area and circularity, vessel density, and perfusion index) of the 6 × 6-mm macular scan. Correlation and multiple regression analyses were performed between optical coherence tomography angiography parameters and previously known diabetes mellitus type 2-related demographic and systemic characteristics, and serum biochemical markers. Results: FAZ parameters and perfusion index of the superficial and deep vascular plexus showed significant correlation with serum insulin level, and homeostasis model assessment indices. In multiple linear regression analysis, low insulin levels predicted increased FAZ areas in both the superficial (β = -0.007; P = 0.030) and deep layers (β = -0.010; P = 0.018) and a decreased perfusion index in the deep layer (β = 0.003; P = 0.001). Conclusions: The expansion and loss of circularity of the FAZ and the decrease in the perfusion index may be affected by insulin resistance and secretory capacity in patients with diabetes mellitus type 2 with no diabetic retinopathy.
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