Evidence map›Paper›PMID 32150612›Full record

SynthesisBlood advances2020

Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines.

Itziar Etxeandia-Ikobaltzeta, Yuan Zhang, Francesca Brundisini, Ivan D Florez, Wojtek Wiercioch, Robby Nieuwlaat, Housne Begum, Carlos A Cuello, Yetiani Roldan, Ru Chen and 16 more

Erratum issuedAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
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  7. Article
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  12. Review
  13. Anticoagulation at the end of life: whether, when, and how to treat.Hematology. American Society of Hematology. Education Program · 2024
    Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Itziar Etxeandia-IkobaltzetaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Yuan ZhangDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Francesca BrundisiniDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Ivan D FlorezDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Wojtek WierciochDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Robby NieuwlaatDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Housne BegumDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Carlos A CuelloDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Yetiani RoldanDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Ru ChenNational Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chengyi DingDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.
Rebecca L MorganDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
John J RivaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Yuqing ZhangDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Rana CharideGRADE Center, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Arnav AgarwalDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Sara BalduzziDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena, Modena, Italy.
Gian Paolo MorganoDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Juan José Yepes-NuñezSchool of Medicine, Universidad de Los Andes, Bogotá, Colombia.
Yasir RehmanDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Ignacio NeumannDepartment of Internal Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Nicole SchwabSickKids Hospital and University of Toronto, Toronto, ON, Canada.
Tejan BaldehDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Cody BraunDepartment of Internal Medicine, Loyola University Medical Center, Maywood, IL.
María Francisca RodríguezFacultad de Medicina, Universidad San Sebastián, Santiago, Chile; and.
Holger J SchünemannDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Values and preferences relate to the importance that patients place on health outcomes (eg, bleeding, having a deep venous thrombosis) and are essential when weighing benefits and harms in guideline recommendations. To inform the American Society of Hematology guidelines for management of venous thromboembolism (VTE) disease, we conducted a systematic review of patients' values and preferences related to VTE. We searched Medline, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature from inception to April of 2018 (PROSPERO-CRD42018094003). We included quantitative and qualitative studies. We followed Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidance for rating the certainty and presenting findings for quantitative research about the relative importance of health outcomes and a grounded theory approach for qualitative thematic synthesis. We identified 14 quantitative studies (2465 participants) describing the relative importance of VTE-related health states in a widely diverse population of patients, showing overall small to important impact on patients' lives (certainty of the evidence from low to moderate). Additionally, evidence from 34 quantitative studies (6424 participants) and 15 qualitative studies (570 participants) revealed that patients put higher value on VTE risk reduction than on the potential harms of the treatment (certainty of evidence from low to moderate). Studies also suggested a clear preference for oral medication over subcutaneous medication (moderate certainty). The observed variability in health state values may be a result of differences in the approaches used to elicit them and the diversity of included populations rather than true variability in values. This finding highlights the necessity to explore the variability induced by different approaches to ascertain values.

Indexed as

HematologyNeoplasmsVenous ThromboembolismAnticoagulantsHeparin, Low-Molecular-WeightHumansUnited StatesAnticoagulantsHeparin, Low-Molecular-Weight

Identifiers

PMID32150612
PMCPMC7065473

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.