Evidence map›Paper›PMID 32151553›Full record

ArticleExperimental hematology2020

Nrf2 deficiency in mice attenuates erythropoietic stress-related macrophage hypercellularity.

Oluwabukola T Gbotosho, Maria G Kapetanaki, Mark Ross, Samit Ghosh, Frances Weidert, Grant C Bullock, Simon Watkins, Solomon F Ofori-Acquah, Gregory J Kato

Open access · greenAbstract read
In one paragraph

Article in Experimental hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Crosstalk betweenGenes · 2023
    Article
  5. Review
  6. Article
  7. The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Oluwabukola T GbotoshoDivision of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Maria G KapetanakiPittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Mark RossCenter for Biologic Imaging, Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA.
Samit GhoshDivision of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; Center for Translational and International Hematology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Frances WeidertPittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Grant C BullockDivision of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Simon WatkinsCenter for Biologic Imaging, Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA.
Solomon F Ofori-AcquahDivision of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; Center for Translational and International Hematology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA; School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
Gregory J KatoDivision of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA. Electronic address: gregorykatomd@gmail.com.
University of Pittsburgh · USUniversity of Ghana · GH

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Cellular and Molecular Mechanisms of Acute Lung Injury in Sickle Cell DiseaseU01HL117721 · NHLBI · EMORY UNIVERSITY · PI DEBAUN, MICHAEL R., JOINER, CLINTON H · 2013 to 2017
$9.4M
SickleGenAfrica:Sickle Cell Disease Genomics Network of AfricaU54HL141011 · NHLBI · UNIVERSITY OF GHANA · PI OFORI-ACQUAH, SOLOMON FIIFI · 2017 to 2021
$5.5M
Novel role of smooth muscle B5 reductase in Sickle Cell DiseaseR01HL133864 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRAUB, ADAM CARL · 2016 to 2019
$2.4M
Mechanisms of endothelial barrier phenotypes in sickle cell diseaseR01HL106192 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OFORI-ACQUAH, SOLOMON FIIFI · 2011 to 2016
$2.1M
SCN5A gene and prolonged QT in sickle cell diseaseR01MD009162 · NIMHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI MAHER, JOSEPH F, MAJUMDAR, SUVANKAR · 2015 to 2019
$1.8M
Ghana-SPARCO: Ghana Sickle Pan-African Research ConsortiumU01HL157004 · NHLBI · KWAME NKRUMAH UNIVERSITY/SCIENCE/TECH · PI OFORI-ACQUAH, SOLOMON FIIFI, SARFO, FRED STEPHEN · 2021 to 2025
$1.4M
Pittsburgh Intensive Training in Hematology ResearchR25HL128640 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NOVELLI, ENRICO M · 2015 to 2019
$382k
NCI NIH HHS P30 CA047904NHLBI NIH HHS R01 HL106192NHLBI NIH HHS R01 HL133864NHLBI NIH HHS R25 HL128640NHLBI NIH HHS U01 HL117721NHLBI NIH HHS U01 HL157004NHLBI NIH HHS U54 HL141011NIMHD NIH HHS R01 MD009162
6 · The paper itself

Abstract

Erythropoiesis in the bone marrow and spleen depends on intricate interactions between the resident macrophages and erythroblasts. Our study focuses on identifying the role of nuclear factor erythroid 2-related factor 2 (Nrf2) during recovery from stress erythropoiesis. To that end, we induced stress erythropoiesis in Nrf2

Indexed as

ErythropoiesisStress, PhysiologicalAnimalsAntigens, DifferentiationBone Marrow CellsFemaleMacrophagesMaleMiceMice, KnockoutNF-E2-Related Factor 2SpleenAntigens, DifferentiationNfe2l2 protein, mouseNF-E2-Related Factor 2

Identifiers

PMID32151553
PMCPMC7237317
OpenAlexW3010121724

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.