Evidence map›Paper›PMID 32153548›Full record

ArticleFrontiers in microbiology2020

Single-Anastomosis Duodenal Jejunal Bypass Improve Glucose Metabolism by Regulating Gut Microbiota and Short-Chain Fatty Acids in Goto-Kakisaki Rats.

Xiang Yu, Zhuangwei Wu, Zhigao Song, Hongbin Zhang, Junfang Zhan, Hao Yu, Hongyan Huang, Baolin Yang, Lang Xie, Xiaojiang Dai and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  7. Anti-Obesity Effects Exerted byFood science & nutrition · 2025
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  12. Anti-obesity effects exerted byFood science & nutrition · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Xiang YuDepartment of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zhuangwei WuDepartment of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zhigao SongCenter for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Hongbin ZhangDepartment of Medical Experimental, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
Junfang ZhanHealth Management Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Hao YuDepartment of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Hongyan HuangDepartment of Metabolic Surgery, UDM Medical Group, Guangzhou, China.
Baolin YangDepartment of Metabolic Surgery, UDM Medical Group, Guangzhou, China.
Lang XieDepartment of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xiaojiang DaiDepartment of Metabolic Surgery, UDM Medical Group, Guangzhou, China.
Weiguo ZhaoDepartment of Metabolic Surgery, UDM Medical Group, Guangzhou, China.
Jinlong YuDepartment of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Liangping WuDepartment of Metabolic Surgery, UDM Medical Group, Guangzhou, China.
Guangzhou University · CNSouthern Medical University · CNZhujiang Hospital · CNGeneral Hospital of Guangzhou Military Command · CNGuangzhou First People's Hospital · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, bariatric surgery has emerged as a promising treatment for type 2 diabetes. Bariatric surgery is known to cause alterations in the relative abundance and composition of gut microbiota, which may lead to alterations in the levels of Short-Chain Fatty Acids (SCFAs) that are produced during fermentation by gut microbes. However, little is known about the mechanism of improved glucose metabolism mediated by gut microbiota following bariatric surgery. The aim of our study was to explore whether changes in gut microbiota and in fecal SCFA could be detected following single-anastomosis duodenal jejunal bypass (DJB-sa) surgery, a type of bariatric surgery, and whether these alterations might be related to the improvement of glucose metabolism. To this end, we performed DJB-sa or SHAM surgery on Goto-Kakisaki (GK) rats. We then compared the glucose metabolism as well as changes in gut microbiota and SCFAs levels between both groups. Our results showed that DJB-sa surgery was associated with a significant decrease in fasting blood glucose (FBG), intraperitoneal glucose tolerance test (IPGTT), and fasting serum insulin (FSI). And, DJB-sa led to a change in the composition of gut microbiota including an increase in the relative abundance of SCFA-producing bacteria (

Indexed as

glucose metabolismgut microbiotashort-chain fatty acidssingle-anastomosis duodenal jejunal bypasstype 2 diabetes

Identifiers

PMID32153548
PMCPMC7047167
OpenAlexW3008008822

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.