Evidence map›Paper›PMID 32156166›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells.

Alisha T Poole, Christopher A Sitko, Caitlin Le, Christian C Naus, Bryan M Hill, Eric A C Bushnell, Vincent C Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Integrated Network Discovery Using Multi-Proteomic Data.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alisha T PooleDepartment of Chemistry, Brandon University, Brandon, Canada.
Christopher A SitkoDepartment of Chemistry, Brandon University, Brandon, Canada.
Caitlin LeDepartment of Chemistry, Brandon University, Brandon, Canada.
Christian C NausDepartment of Cellular and Physiological Sciences, University of British Columbia, Life Science Institute, Vancouver, Canada.
Bryan M HillDepartment of Chemistry, Brandon University, Brandon, Canada.
Eric A C BushnellDepartment of Chemistry, Brandon University, Brandon, Canada.
Vincent C ChenDepartment of Chemistry, Brandon University, Brandon, Canada.
Brandon University · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is the deadliest and the most common primary malignant brain tumour. The median survival for patients with GBM is around one year due to the nature of glioma cells to diffusely invade that make the complete surgical resection of tumours difficult. Based upon the connexin43 (Cx43) model of glioma migration we have developed a computational framework to evaluate MMP inhibition in materials relevant to GBM. Using the ilomastat Leu-Trp backbone, we have synthesised novel sulphonamides and monitored the performance of these compounds in conditioned media expressing MMP3. From the results discussed herein we demonstrate the performance of sulfonamide based MMPIs included AP-3, AP-6, and AP-7.

Indexed as

Antineoplastic AgentsBrain NeoplasmsCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorGlioblastomaHumansMatrix Metalloproteinase 3Matrix Metalloproteinase InhibitorsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipSulfonamidesTumor Cells, CulturedAntineoplastic AgentsMatrix Metalloproteinase 3Matrix Metalloproteinase InhibitorsMMP3 protein, humanSulfonamidesglioblastoma multiformeilomastatinhibitionMatrix metalloproteinase

Identifiers

PMID32156166
PMCPMC7144313
OpenAlexW3010786690

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.