Evidence map›Paper›PMID 32158091›Full record

ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2020

A Prospective Observational Multi-institutional Study on Invasive Fungal Infections Following Chemotherapy for Acute Myeloid Leukemia (MISFIC Study): A Real World Scenario from India.

Biju George, Hari Menon, Dinesh Bhurani, Sharat Damodar, Shashi Apte, Tulika Seth, Ajay Sharma, Radhe Shyam, Pankaj Malhotra, Jose Easow and 12 more

Open access · greenAbstract read
In one paragraph

Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. A Prospective Study to Evaluate the Effect of Therapeutic Drug Monitoring-Based Posaconazole Prophylaxis on Invasive Fungal Infection Rate During Acute Myeloid Leukemia Induction Therapy.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 1 country.

Biju George1Christian Medical College, Vellore, India.ORCID 0000-0002-9847-9501
Hari Menon2Tata Memorial Hospital, Mumbai, India.
Dinesh Bhurani3Rajiv Gandhi Cancer Institute, New Delhi, India.
Sharat DamodarNarayana Hirudalaya, Bengaluru, India.
Shashi ApteSahayadri Hospital, Pune, India.
Tulika Seth6All India Institute of Medical Sciences, New Delhi, India.
Ajay SharmaR and R Hospital, New Delhi, India.
Radhe Shyam8HCG Hospital, Bengaluru, India.
Pankaj Malhotra9Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Jose EasowApollo Specialty Hospital, Chennai, India.
Kavitha M Lakshmi1Christian Medical College, Vellore, India.
Narendra Agrawal3Rajiv Gandhi Cancer Institute, New Delhi, India.
Manju Sengar2Tata Memorial Hospital, Mumbai, India.
K S NatarajNarayana Hirudalaya, Bengaluru, India.
Rayaz Ahmed3Rajiv Gandhi Cancer Institute, New Delhi, India.
Sanjeevan SharmaR and R Hospital, New Delhi, India.
Alka Khadwal9Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Gaurav Prakash9Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Aby Abraham1Christian Medical College, Vellore, India.
Anup Devasia1Christian Medical College, Vellore, India.
Anu Korula1Christian Medical College, Vellore, India.
Vikram Mathews1Christian Medical College, Vellore, India.
Christian Medical College, Vellore · INPost Graduate Institute of Medical Education and Research · INRajiv Gandhi Cancer Institute and Research Centre · INNarayana Health · INTata Memorial Hospital · INAll India Institute of Medical Sciences · INApollo Hospitals · INHCG Cancer Hospital · INSahyadri Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a prospective multi-centre observational study to understand the incidence of IFI in patients with AML in India with use of anti-fungal prophylaxis. All patients with AML receiving either induction chemotherapy or salvage chemotherapy between November 2014 and February 2016 were included in this prospective observational study from 10 Indian centres. IFI was defined as per the revised EORTC-MSG criteria. Data on type of chemotherapy used, type of anti-fungal prophylaxis used, time to neutrophil recovery, incidence of IFI and survival were collected. Two hundred patients (118 male and 82 females) with a median age of 35 years (range: 2-66) were recruited. One hundred and eighty-six (93%) had newly diagnosed acute myeloid leukemia (AML) while 14 (7%) had relapsed disease. IFI occurred in 53 patients (26.5%) with proven or probable IFI occurring in 17 (8.5%). Use of posaconazole prophylaxis (

Indexed as

AMLFungal infectionIncidenceIndia

Identifiers

PMID32158091
PMCPMC7042421
OpenAlexW2970088537

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.