ArticleBMJ open2020
Effect of resting heart rate on the risk of all-cause death in Chinese patients with hypertension: analysis of the Kailuan follow-up study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Trial
- Chinese Guidelines for the Prevention and Treatment of Hypertension (2024 revision).Journal of geriatric cardiology : JGC · 2025Article
- Intercorrelated variability in blood and hemodynamic biomarkers reveals physiological network in hemodialysis patients.Scientific reports · 2023Article
- Effect of baseline resting heart rate on the risk of all-cause death in Chinese patients with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Initial in-hospital heart rate is associated with long-term survival in patients with acute ischemic stroke.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- Article
- A Nomogram for Predicting the Risk of Critical Limb Ischemia in Adults with Hypertension: A Retrospective Study.International journal of general medicine · 2022Article
- Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals.Scientific reports · 2021Article
- Effect of Heart Rate on Major Adverse Cardiovascular Events in Hypertensive Patients with Different Ages and Genders.China CDC weekly · 2021Article
- Heart rate fluctuation predicts mortality in critically ill patients in the intensive care unit: a retrospective cohort study.Annals of translational medicine · 2021Article
- Admission Resting Heart Rate as an Independent Predictor of All-Cause Mortality in Elderly Patients with Hip Fracture.International journal of general medicine · 2021Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious studies have shown that an elevated heart rate is associated with a higher risk of cardiovascular events. This study aimed to prospectively examine the relationship between resting heart rate (RHR) and all-cause mortality in Chinese patients with hypertension.
designAn observational, prospective and population-based cohort study.
settingThe Kailuan cohort study was conducted in Tangshan City in northern China.
participantsWe enrolled 46 561 patients who did not receive beta-blocker treatment and were diagnosed with hypertension for the first time during an employee health examination in Kailuan Group in 2006 and 2008. OUTCOME: The primary outcome of this study was all-cause mortality.
methodsThe patients in this study were followed for 9.25±1.63 years. All patients were followed up face to face every 2 years. According to the distribution of RHR in the study population, RHR was categorised into five groups on the basis of quintiles: Q1: RHR ≤68 beats per minute (bpm); Q2: RHR >68 and ≤72 bpm; Q3: RHR >72 and ≤76 bpm; Q4: RHR >76 and ≤82 bpm; Q5: RHR >82 bpm. Cox proportional hazards model, which was adjusted for traditional risk factors, was used.
resultsDuring follow-up, 4751 deaths occurred. After adjustment for potential confounders, restricted cubic spline regression showed that the risk of all-cause mortality increased with heart rate. In multivariate Cox regression analyses adjusted for age, sex and major covariates, the HR for all-cause mortality was 1.31 (95% CI 1.27 to 1.33) in the highest quintile group (Q5) compared with the lowest quintile group (Q1).
conclusionAn increase in RHR is a long-term risk factor of all-cause mortality in Chinese patients with hypertension. TRIAL REGISTRATION NUMBER: ChiCTR-TNC-11001489.
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