Evidence map›Paper›PMID 32162210›Full record

ReviewGeroScience2020

Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging.

Janko Nikolich-Žugich, Luka Čicin-Šain, Donna Collins-McMillen, Sarah Jackson, Annette Oxenius, John Sinclair, Christopher Snyder, Mark Wills, Niels Lemmermann

Open access · bronzeAbstract readReview
In one paragraph

Review in GeroScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 62 citations in OpenAlex.

  1. The ageing immune system and its battle with viruses.The Journal of general virology · 2026
    Review
  2. Distribution characteristics and influencing factors of active cytomegalovirus infection in patients with hematological malignancies complicated with sepsis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Janko Nikolich-ŽugichDepartment of Immunobiology and the University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA. nikolich@email.arizona.edu.ORCID 0000-0001-5830-5323
Luka Čicin-ŠainDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Donna Collins-McMillenDepartment of Immunobiology and the University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA.
Sarah JacksonDivision of Infectious Diseases, Department of Medicine, University of Cambridge, Addenbrookes Hospital, Level 5, Box 157, Hills Road, Cambridge, CB2 0QQ, UK.
Annette OxeniusInstitute of Microbiology, ETH Zurich, 8093, Zurich, Switzerland.
John SinclairDivision of Infectious Diseases, Department of Medicine, University of Cambridge, Addenbrookes Hospital, Level 5, Box 157, Hills Road, Cambridge, CB2 0QQ, UK.
Christopher SnyderDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Mark WillsDivision of Infectious Diseases, Department of Medicine, University of Cambridge, Addenbrookes Hospital, Level 5, Box 157, Hills Road, Cambridge, CB2 0QQ, UK.
Niels LemmermannInstitute for Virology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany.
University of Cambridge · GBUniversity of Arizona · USETH Zurich · CHJohannes Gutenberg University Mainz · DEMedizinische Hochschule Hannover · DEThomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytomegalovirus (CMV) is one of the largest and most ubiquitous latent persistent viruses. Most humans are infected with CMV early in life, and all immunocompetent humans spend several decades living with CMV. In the vast majority of the hosts, CMV does not cause manifest disease, and CMV therefore can be considered part of normal aging for 50-90% of the human population worldwide. Experimental, clinical, and epidemiological studies suggest that CMV carriage can have nuanced outcomes, including both potentially harmful and potentially beneficial impacts on the host. We here present a summary of the 7th International Workshop on CMV and Immunosenescence, covering various aspects of the interplay between CMV and its mammalian hosts in the context of virus spread, immune evasion, antiviral immunity, as well as the impact on health span and aging.

Indexed as

AgingCytomegalovirus InfectionsImmunosenescenceAnimalsCytomegalovirusHumansAgingCytomegalovirusImmune evasionImmunityLatency

Identifiers

PMID32162210
PMCPMC7205956
OpenAlexW3011043290

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.