SynthesisCanadian family physician Medecin de famille canadien2020
PEER umbrella systematic review of systematic reviews: Management of osteoarthritis in primary care.
Synthesis in Canadian family physician Medecin de famille canadien, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 250 citations in OpenAlex.
- PEER systematic review of randomized controlled trials: Management of chronic neuropathic pain in primary care.Canadian family physician Medecin de famille canadien · 2021Pooled it
- PEER systematic review of randomized controlled trials: Management of chronic low back pain in primary care.Canadian family physician Medecin de famille canadien · 2021Pooled it
- Masks for prevention of viral respiratory infections among health care workers and the public: PEER umbrella systematic review.Canadian family physician Medecin de famille canadien · 2020Pooled it
- Review
- Association of long-term use of non-steroidal anti-inflammatory drugs with knee osteoarthritis: a prospective multi-cohort study over 4-to-5 years.Scientific reports · 2024Article
- The efficacy of a nutritional supplement containing green-lipped mussel, curcumin and blackcurrant leaf extract in dogs and cats with osteoarthritis.Veterinary medicine and science · 2022Article
- PEER simplified chronic pain guideline: Management of chronic low back, osteoarthritic, and neuropathic pain in primary care.Canadian family physician Medecin de famille canadien · 2022Article
- Article
- Effect of diet-induced weight loss on osteoarthritic knee pain.Canadian family physician Medecin de famille canadien · 2022Article
- Glucosamine as a Treatment for Osteoarthritis: What If It's True?Frontiers in pharmacology · 2022Review
- Are glucosamine and chondroitin natural remedies for osteoarthritis?Canadian family physician Medecin de famille canadien · 2021Article
- La glucosamine et la chondroïtine sont-elles des remèdes naturels pour l'arthrose?Canadian family physician Medecin de famille canadien · 2021Article
- Exercise-induced osteoarthritis.Canadian family physician Medecin de famille canadien · 2020Article
- Article
- The rise ofCanadian family physician Medecin de famille canadien · 2020Article
- Misleading communication aid.Canadian family physician Medecin de famille canadien · 2020Article
- Article
- Improving osteoarthritis care in family practice.Canadian family physician Medecin de famille canadien · 2020Article
- Article
- PEER simplified decision aid: osteoarthritis treatment options in primary care.Canadian family physician Medecin de famille canadien · 2020Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine how many patients with chronic osteoarthritis pain respond to various non-surgical treatments. DATA SOURCES: PubMed and the Cochrane Library. STUDY SELECTION: Published systematic reviews of randomized controlled trials (RCTs) that included meta-analysis of responder outcomes for at least 1 of the following interventions were included: acetaminophen, oral nonsteroidal anti-inflammatory drugs (NSAIDs), topical NSAIDs, serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, cannabinoids, counseling, exercise, platelet-rich plasma, viscosupplementation, glucosamine, chondroitin, intra-articular corticosteroids, rubefacients, or opioids. SYNTHESIS: In total, 235 systematic reviews were included. Owing to limited reporting of responder meta-analyses, a post hoc decision was made to evaluate individual RCTs with responder analysis within the included systematic reviews. New meta-analyses were performed where possible. A total of 155 RCTs were included. Interventions that led to more patients attaining meaningful pain relief compared with control included exercise (risk ratio [RR] of 2.36; 95% CI 1.79 to 3.12), intra-articular corticosteroids (RR = 1.74; 95% CI 1.15 to 2.62), SNRIs (RR = 1.53; 95% CI 1.25 to 1.87), oral NSAIDs (RR = 1.44; 95% CI 1.36 to 1.52), glucosamine (RR = 1.33; 95% CI 1.02 to 1.74), topical NSAIDs (RR = 1.27; 95% CI 1.16 to 1.38), chondroitin (RR = 1.26; 95% CI 1.13 to 1.41), viscosupplementation (RR = 1.22; 95% CI 1.12 to 1.33), and opioids (RR = 1.16; 95% CI 1.02 to 1.32). Preplanned subgroup analysis demonstrated no effect with glucosamine, chondroitin, or viscosupplementation in studies that were only publicly funded. When trials longer than 4 weeks were analyzed, the benefits of opioids were not statistically significant.
conclusionInterventions that provide meaningful relief for chronic osteoarthritis pain might include exercise, intra-articular corticosteroids, SNRIs, oral and topical NSAIDs, glucosamine, chondroitin, viscosupplementation, and opioids. However, funding of studies and length of treatment are important considerations in interpreting these data.
Indexed as
Identifiers
32165479PMC8302337W3011362252What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.