Evidence map›Paper›PMID 32169887›Full record

Trial reportCancer prevention research (Philadelphia, Pa.)2020

Dietary Advanced Glycation End-products (AGE) and Risk of Breast Cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO).

Omonefe O Omofuma, David P Turner, Lindsay L Peterson, Anwar T Merchant, Jiajia Zhang, Susan E Steck

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Cancer prevention research (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Lifestyle-Based Approaches to Cancer Prevention and Treatment: Diet, Physical Activity, and Integrative Strategies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Are dietary and serum advanced glycation end-products related to inflammation and oxidation biomarkers in breast cancer patients: a follow-up study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  19. Effects of AGEs, sRAGE and HMGB1 on Clinical Outcomes in Multiple Myeloma.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Omonefe O OmofumaDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
David P TurnerMedical University of South Carolina, Charleston, South Carolina.
Lindsay L PetersonDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.ORCID 0000-0002-5012-7347
Anwar T MerchantDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.ORCID 0000-0003-1045-5079
Jiajia ZhangDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
Susan E SteckDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. stecks@mailbox.sc.edu.ORCID 0000-0002-3201-9537
University of South Carolina · USMedical University of South Carolina · USWashington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Nada A. Abumrad · 1999 to 2026
$30.2M
South Carolina Cancer Disparities Research Center (SC CADRE)U54CA210962 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MAGWOOD, GAYENELL SMITH · 2017 to 2023
$6.7M
South Carolina Cancer Disparities Research Center (SC CaDRe)U54CA210963 · NCI · SOUTH CAROLINA STATE UNIVERSITY · PI MCCRARY-QUARLES, AUDREY · 2017 to 2023
$6.1M
Lifestyle associated reactive metabolites and their negative impact on breast cancer riskR01CA245143 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI FINDLAY, VICTORIA JANE, TURNER, DAVID PAUL · 2020 to 2024
$2.1M
The Generation of Clinically Annotated and Molecularly Characterized PDX Animal Models from Racially and Ethnically Diverse Prostate Cancer TissueR21CA194469 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TURNER, DAVID PAUL · 2015 to 2016
$420k
NCI NIH HHS L30 CA220736NCI NIH HHS R01 CA245143NCI NIH HHS R21 CA194469NCI NIH HHS U54 CA210962NCI NIH HHS U54 CA210963NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

Advanced glycation end-products (AGEs) are implicated in the pathogenesis of several chronic diseases including cancer. AGEs are produced endogenously but can also be consumed from foods. AGE formation in food is accelerated during cooking at high temperatures. Certain high fat or highly processed foods have high AGE values. The objective of the study was to assign and quantify N

Indexed as

AgedBreast NeoplasmsColorectal NeoplasmsDietEarly Detection of CancerFemaleFollow-Up StudiesGlycation End Products, AdvancedHumansLung NeoplasmsLysineMiddle AgedOvarian NeoplasmsPrognosisProspective StudiesRisk FactorsGlycation End Products, AdvancedLysineN(6)-carboxymethyllysine

Identifiers

PMID32169887
PMCPMC7335328
OpenAlexW3012471333

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.