ArticlePhysiological reports2020
Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine.
Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- The physiology of MASLD: molecular pathways between liver and adipose tissues.Clinical science (London, England : 1979) · 2025Review
- Age-Dependent Differences in Postprandial Bile-Acid Metabolism and the Role of the Gut Microbiome.Microorganisms · 2024Article
- Altered fecal bile acid composition in active ulcerative colitis.Lipids in health and disease · 2023Article
- Duodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes.American journal of physiology. Endocrinology and metabolism · 2022Observational
- Dynamics and determinants of human plasma bile acid profiles during dietary challenges.Frontiers in nutrition · 2022Article
- Differential Effects of One Meal per Day in the Evening on Metabolic Health and Physical Performance in Lean Individuals.Frontiers in physiology · 2021Article
- Distinct Postprandial Bile Acids Responses to a High-Calorie Diet in Men Volunteers Underscore Metabolically Healthy and Unhealthy Phenotypes.Nutrients · 2020Article
- Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine.Physiological reports · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBile acids are multifaceted metabolic compounds that signal to cholesterol, glucose, and lipid homeostasis via receptors like the Farnesoid X Receptor (FXR) and transmembrane Takeda G protein-coupled receptor 5 (TGR5). The postprandial increase in plasma bile acid concentrations is therefore a potential metabolic signal. However, this postprandial response has a high interindividual variability. Such variability may affect bile acid receptor activation.
methodsIn this study, we analyzed the inter- and intraindividual variability of fasting and postprandial bile acid concentrations during three identical meals on separate days in eight healthy lean male subjects using a statistical and mathematical approach. MAIN
findingsThe postprandial bile acid responses exhibited large interindividual and intraindividual variability. The individual mathematical models, which represent the enterohepatic circulation of bile acids in each subject, suggest that interindividual variability results from quantitative and qualitative differences of distal active uptake, colon transit, and microbial bile acid transformation. Conversely, intraindividual variations in gallbladder kinetics can explain intraindividual differences in the postprandial responses.
conclusionsWe conclude that there is considerable inter- and intraindividual variation in postprandial plasma bile acid levels. The presented personalized approach is a promising tool to identify unique characteristics of underlying physiological processes and can be applied to investigate bile acid metabolism in pathophysiological conditions.
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