ArticleFrontiers in psychiatry2020
Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Delirious Mania with Mild Encephalitis and a Reversible Splenial Lesion Successfully Treated with Electroconvulsive Therapy: A Case Report.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Retrospective chart review of cases of steroid-responsive catatonia: exploring a potential autoimmune aetiology.BJPsych open · 2025Article
- Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS).PCN reports : psychiatry and clinical neurosciences · 2024Article
- Transient splenial lesion syndrome in bipolar-II disorder: a case report highlighting reversible brain changes during hypomanic episodes.Frontiers in psychiatry · 2023Article
- Delirious Mania in an Elderly, Challenges in Diagnosis and Treatment.Case reports in psychiatry · 2023Article
- Article
- Case of refractory delirious mania responsive to lithium.BJPsych open · 2021Article
- The Role of Cholesterol and Fatty Acids in the Etiology and Diagnosis of Autism Spectrum Disorders.International journal of molecular sciences · 2021Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mild encephalitis with reversible splenial lesion is a rare clinic-radiological entity presenting with neurological and neuropsychiatric symptoms associated with cerebral lesion/s. Delirious mania is a severe psychiatric syndrome characterized by acute onset of delirium, excitement, and psychosis with a high mortality rate. In this paper, we present a case report of mild encephalitis with reversible splenial lesion clinically presenting as delirious mania and evolving into life-threatening multi-organ failure. The patient was treated with aripiprazole and benzodiazepine with poor effect and, after 4 days, the patient's condition significantly worsened requiring transfer to the intensive care unit where deep sedation with propofol was started. Our findings are in contrast with the traditional literature description of self-resolving and harmless mild encephalitis with reversible splenial lesion. Moreover, rapid clinical recovery and the progressive improvement of psychiatric symptoms after deep sedation with propofol in this case-considering propofol's neuroprotective and anti-inflammatory effects-supports the notion of propofol-mediated deep sedation for the treatment of severe manic symptoms associated with life-threatening conditions. Little is known about neural markers of the manic state, and the corpus callosum has been described to be involved in bipolar disorder. Abnormalities in this structure may represent a marker of vulnerability for this disorder.
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