ArticleFrontiers in immunology2020
Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice.
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Maternal Social Support Reshapes the Offspring Brain Transcriptome to Buffer Prenatal Stress in Mice.Research square · 2026Article
- Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives.Acta pharmacologica Sinica · 2026Review
- Early Life Stress and Adversity in Children: Neuroendocrine Mechanisms, Epigenetic Regulation, and Lifespan Developmental Outcomes-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Article
- Maternal factors contributing to variability in gut microbiota and gastrointestinal function in autism spectrum disorders.World journal of psychiatry · 2025Review
- Understanding the Causal Impact of Elevated Maternal Stress During Pregnancy: A Systematic Literature Review of Guinea Pig Models.bioRxiv : the preprint server for biology · 2025Article
- Stress-induced developmental plasticity and spontaneous preterm birth: A justice-oriented eco-evo-devo review.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Prenatal stress and fluoxetine exposure in BTBR and B6 mice differentially affects autism-like behaviors in adult male and female offspring.Physiology & behavior · 2025Article
- Antenatal depressive and anxiety symptoms in early pregnancy and offspring allergic diseases during toddlerhood.World journal of pediatrics : WJP · 2025Article
- Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations.Communications biology · 2025Article
- Maternal Psychotherapy Addressing Generational Stress is Associated with Lower Preterm Birth Risk: The Pforzheim Study.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Optimizing Newborn Outcomes in Cesarean Sections: A Comparative Analysis of Stress Indicators under General and Spinal Anesthesia.Children (Basel, Switzerland) · 2024Article
- Canine Amniotic Fluid at Birth Holds Information about Neonatal Antibody Titres against Core Vaccine Viruses.Veterinary sciences · 2024Article
- IMplementation of the Preterm Birth Surveillance PAthway: a RealisT evaluation (The IMPART Study).Implementation science communications · 2024Article
- Effects of the commensal microbiota on spleen and mesenteric lymph node immune function: investigation in a germ-free piglet model.Frontiers in microbiology · 2024Article
- Article
- The Impact of Stress, Microbial Dysbiosis, and Inflammation on Necrotizing Enterocolitis.Microorganisms · 2023Review
- Stress of Prematurity in the Experience of the COVID-19 Pandemic-Current State of Knowledge.Life (Basel, Switzerland) · 2023Review
- A Review of the Impact of Maternal Prenatal Stress on Offspring Microbiota and Metabolites.Metabolites · 2023Review
- Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Maternal stress is a well-established risk factor for preterm birth and has been associated with adverse neonatal outcomes in the first and subsequent generations, including increased susceptibility to disease and lasting immunological changes. However, a causal link between prenatal maternal stress and preterm birth, as well as compromised neonatal immunity, has yet to be established. To fill this gap in knowledge, we used a murine model of prenatal maternal stress across three generations and high-dimensional flow cytometry to evaluate neonatal adaptive immunity. We report that recurrent prenatal maternal stress induced preterm birth in the first and second filial generations and negatively impacted early neonatal growth. Strikingly, prenatal maternal stress induced a systematic reduction in T cells and B cells, the former including regulatory CD4+ T cells as well as IL-4- and IL-17A-producing T cells, in the second generation. Yet, neonatal adaptive immunity gained resilience against prenatal maternal stress by the third generation. We also show that the rate of prenatal maternal stress-induced preterm birth can be reduced upon cessation of stress, though neonatal growth impairments persisted. These findings provide evidence that prenatal maternal stress causes preterm birth and affects neonatal immunity across generations, adverse effects that can be ameliorated upon cessation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.