ArticleScientific reports2020
The control mechanisms of heart rate dynamics in a new heart rate nonlinear time series model.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- Cardiometabolic Risk Determinants in a University Community: Beyond Chronological Age to Anthropometric Impact.Healthcare (Basel, Switzerland) · 2026Article
- Task difficulty influences heart rate variability: evidence from a pilot study using a multi-level mental arithmetic task.Scientific reports · 2026Article
- Brain‑heart axis: Neurostimulation techniques in ischemic heart disease (Review).International journal of molecular medicine · 2025Review
- The impact of overweight-obesity on heart rate variability among Indian adults - A cross-sectional study.Journal of family medicine and primary care · 2025Article
- Heart rate variability and its modulation by nutrients: a narrative review on implications for cardiovascular aging.Frontiers in neuroscience · 2025Review
- Computational modeling of autonomic nerve stimulation: Vagus et al.Current opinion in biomedical engineering · 2024Article
- Relationship between central autonomic effective connectivity and heart rate variability: A Resting-state fMRI dynamic causal modeling study.NeuroImage · 2024Article
- Psychophysiological reactions during the trauma-film paradigm and their predictive value for intrusions.European journal of psychotraumatology · 2023Article
- Entropy of Heart Rate on Self-Selected Interval Exercises in Older Women.International journal of exercise science · 2023Article
- When blood pressure refuses to budge: exploring the complexity of resistant hypertension.Frontiers in cardiovascular medicine · 2023Review
- Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling.The Journal of general physiology · 2022Review
- Frailty Identification Using Heart Rate Dynamics: A Deep Learning Approach.IEEE journal of biomedical and health informatics · 2022Article
- Pseudo and resistant hypertension: A chaotic perspective.Journal of clinical hypertension (Greenwich, Conn.) · 2022Review
- Slow-paced breathing enhancing emotional control accompanied with the change of the ∼0.1 Hz heartbeat evoked EEG.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The control mechanisms and implications of heart rate variability (HRV) under the sympathetic (SNS) and parasympathetic nervous system (PNS) modulation remain poorly understood. Here, we establish the HR model/HRV responder using a nonlinear process derived from Newton's second law in stochastic self-restoring systems through dynamic analysis of physiological properties. We conduct model validation by testing, predictions, simulations, and sensitivity and time-scale analysis. We confirm that the outputs of the HRV responder can be accepted as the real data-generating process. Empirical studies show that the dynamic control mechanism of heart rate is a stable fixed point, rather than a strange attractor or transitions between a fixed point and a limit cycle; HR slope (amplitude) may depend on the ratio of cardiac disturbance or metabolic demand mean (standard deviation) to myocardial electrical resistance (PNS-SNS activity). For example, when metabolic demands remain unchanged, HR amplitude depends on PNS to SNS activity; when autonomic activity remains unchanged, HR amplitude during resting reflects basal metabolism. HR parameter alterations suggest that age-related decreased HRV, ultrareduced HRV in heart failure, and ultraelevated HRV in ST segment alterations refer to age-related decreased basal metabolism, impaired myocardial metabolism, and SNS hyperactivity triggered by myocardial ischemia, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.