Evidence map›Paper›PMID 32180905›Full record

ArticleComputational and structural biotechnology journal2020

Catestatin improves insulin sensitivity by attenuating endoplasmic reticulum stress:

Abhijit Dasgupta, Gautam K Bandyopadhyay, Indrani Ray, Keya Bandyopadhyay, Nirmalya Chowdhury, Rajat K De, Sushil K Mahata

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

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  19. Chemical Factory-Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Abhijit DasguptaDepartment of Data Science, School of Interdisciplinary Studies, University of Kalyani, Kalyani, Nadia 741235, West Bengal, India.
Gautam K BandyopadhyayDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0732, USA.
Indrani RayMachine Intelligence Unit, Indian Statistical Institute, 203 B.T. Road, Kolkata 700108, India.
Keya BandyopadhyayDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0732, USA.
Nirmalya ChowdhuryDepartment of Computer Science & Engineering, Jadavpur University, Kolkata 700032, India.
Rajat K DeMachine Intelligence Unit, Indian Statistical Institute, 203 B.T. Road, Kolkata 700108, India.
Sushil K MahataVA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.
University of California San Diego · USIndian Statistical Institute · INJadavpur University · INUniversity of Kalyani · IN

Funding

JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
Role of Chromogranin A in Metabolic SyndromeI01BX000323 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI MAHATA, SUSHIL K · 2011 to 2013
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Catestatin improves glucose homeostasis and insulin sensitivity in diet-induced obese miceI01BX003934 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI MAHATA, SUSHIL K · 2018 to 2021
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BLRD VA I01 BX000323BLRD VA I01 BX003934NIH HHS S10 OD023527
6 · The paper itself

Abstract

Obesity is characterized by a state of chronic, unresolved inflammation in insulin-targeted tissues. Obesity-induced inflammation causes accumulation of proinflammatory macrophages in adipose tissue and liver. Proinflammatory cytokines released from tissue macrophages inhibits insulin sensitivity. Obesity also leads to inflammation-induced endoplasmic reticulum (ER) stress and insulin resistance. In this scenario, based on the data (specifically patterns) generated by our

Indexed as

CatestatinChromogranin AEndoplasmic reticulum stressInsulin sensitivityObesityPID controller

Identifiers

PMID32180905
PMCPMC7063178
OpenAlexW3008879596

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.