Evidence map›Paper›PMID 32187737›Full record

ArticleEnvironmental and molecular mutagenesis2020

Testing of acetaminophen in support of the international multilaboratory in vivo rat Pig-a assay validation trial.

Bas-Jan van der Leede, Sandy Weiner, Terry Van Doninck, Kathleen De Vlieger, Ann Schuermans, Fetene Tekle, Helena Geys, Marjolein van Heerden, Sandra De Jonghe, Jacky Van Gompel

Open access · hybridAbstract readMulticenter StudyValidation Study
In one paragraph

Article in Environmental and molecular mutagenesis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Bas-Jan van der LeedeJanssen Research & Development, Beerse, Antwerp, Belgium.
Sandy WeinerJanssen Research & Development, Spring House, Pennsylvania, USA.
Terry Van DoninckJanssen Research & Development, Beerse, Antwerp, Belgium.
Kathleen De VliegerJanssen Research & Development, Beerse, Antwerp, Belgium.
Ann SchuermansJanssen Research & Development, Beerse, Antwerp, Belgium.
Fetene TekleJanssen Research & Development, Beerse, Antwerp, Belgium.
Helena GeysJanssen Research & Development, Beerse, Antwerp, Belgium.
Marjolein van HeerdenJanssen Research & Development, Beerse, Antwerp, Belgium.
Sandra De JongheJanssen Research & Development, Beerse, Antwerp, Belgium.
Jacky Van GompelJanssen Research & Development, Beerse, Antwerp, Belgium.
Janssen (Belgium) · BESpringhouse · US

Funding

Janssen Pharmaceutical Companies of Johnson & JohnsonJohnson & Johnson Consumer, Inc, McNeil Consumer Healthcare Division
6 · The paper itself

Abstract

Acetaminophen, a nonmutagenic compound as previously concluded from bacteria, in vitro mammalian cell, and in vivo transgenic rat assays, presented a good profile as a nonmutagenic reference compound for use in the international multilaboratory Pig-a assay validation. Acetaminophen was administered at 250, 500, 1,000, and 2,000 mg·kg

Indexed as

Biological AssayInternationalityLaboratoriesMutagenicity TestsAcetaminophenAnimalsComet AssayMaleMicronucleus TestsMutagensRats, Sprague-DawleyReproducibility of ResultsAcetaminophenMutagensflow cytometryglycosyl phosphatidylinositolin vivomutation assayred blood cellsreticulocytes

Identifiers

PMID32187737
PMCPMC7317746
OpenAlexW3011967628

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.