Evidence map›Paper›PMID 32188134›Full record

ReviewInternational journal of molecular sciences2020

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview.

Sandra Torres, Zeinab Abdullah, Maximilian J Brol, Claus Hellerbrand, Mercedes Fernandez, Romina Fiorotto, Sabine Klein, Philipp Königshofer, Christian Liedtke, Sophie Lotersztajn and 7 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. [Research progress of single-cell sequencing technology in liver diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Novel approaches to liver disease diagnosis and modeling.Translational gastroenterology and hepatology · 2021
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 6 countries.

Sandra TorresDepartment of Internal Medicine I, Goethe University Frankfurt, 60590 Frankfurt, Germany.
Zeinab AbdullahInstitute of Molecular Medicine and Experimental Immunology, University Clinic, 53127 Bonn, Germany.
Maximilian J BrolDepartment of Internal Medicine I, University Clinic, 53127 Bonn, Germany.
Claus HellerbrandInstitute of Biochemistry, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Mercedes FernandezAngiogenesis in Liver Disease Research Group, IDIBAPS Biomedical Research Institute, University of Barcelona, 08036 Barcelona, Spain.
Romina FiorottoYale University School of Medicine, Yale Liver Center, Department of Internal Medicine, New Haven, CT 06520, USA.
Sabine KleinDepartment of Internal Medicine I, Goethe University Frankfurt, 60590 Frankfurt, Germany.
Philipp KönigshoferDiv. of Gastroenterology and Hepatology, Dept. of Internal Medicine III, Medical University of Vienna, A-1090 Vienna, Austria.
Christian LiedtkeDepartment of Internal Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Sophie LotersztajnInserm UMR-1149, Centre de Recherche sur l'Inflammation, 75890 Paris, France.
Yulia A NevzorovaDepartment of Internal Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Robert SchierwagenDepartment of Internal Medicine I, Goethe University Frankfurt, 60590 Frankfurt, Germany.
Thomas ReibergerDiv. of Gastroenterology and Hepatology, Dept. of Internal Medicine III, Medical University of Vienna, A-1090 Vienna, Austria.
Frank Erhard UschnerDepartment of Internal Medicine I, Goethe University Frankfurt, 60590 Frankfurt, Germany.
Frank TackeDepartment of Hepatology & Gastroenterology, Charité University Medicine Berlin, 10117 Berlin, Germany.
Ralf WeiskirchenInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, (IFMPEGKC), University Hospital Aachen, D-52074 Aachen, Germany.
Jonel TrebickaDepartment of Internal Medicine I, Goethe University Frankfurt, 60590 Frankfurt, Germany.
Goethe University Frankfurt · DEMedical University of Vienna · ATCharité - Universitätsmedizin Berlin · DEConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESFriedrich-Alexander-Universität Erlangen-Nürnberg · DEInserm · FRRWTH Aachen University · DEUniversidad Complutense de Madrid · ESUniversitätsklinikum Aachen · DEUniversity Hospital Bonn · DEYale University · US

Funding

Deutsche Forschungsgemeinschaft SFB TRR57, CRC1382H2020 European Research Council 668031H2020 European Research Council 731875H2020 European Research Council 825694
6 · The paper itself

Abstract

Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, paving the path for 2D and 3D microscopy and high-throughput assays (e.g., bulk or single-cell RNA sequencing). The use of stem cell and organoid research will help to decipher the pathophysiology of liver diseases and the interaction between various parenchymal and non-parenchymal liver cells. Furthermore, sophisticated animal models of liver disease allow for the in vivo assessment of fibrogenesis, portal hypertension and hepatocellular carcinoma (HCC) and for the preclinical testing of therapeutic strategies. The purpose of this review is to portray in detail novel in vitro and in vivo methods for the study of liver cell biology that had been presented at the workshop of the 8th meeting of the European Club for Liver Cell Biology (ECLCB-8) in October of 2018 in Bonn, Germany.

Indexed as

Cell BiologyAnimalsCarcinoma, HepatocellularCell CommunicationCell Culture TechniquesCytological TechniquesDisease Models, AnimalFatty LiverGene ExpressionGermanyHepatocytesHumansHypertension, PortalLiverLiver NeoplasmsNon-alcoholic Fatty Liver Diseasefibrogenesishepatic stellate cellshepatocellular cancerin vitro modelssteatosis

Identifiers

PMID32188134
PMCPMC7139397
OpenAlexW3011699256

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.