Evidence map›Paper›PMID 32190059›Full record

ArticleStem cells international2020

Intrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy.

Elzbieta Szczepanik, Hanna Mierzewska, Dorota Antczak-Marach, Anna Figiel-Dabrowska, Iwona Terczynska, Jolanta Tryfon, Natalia Krzesniak, Bartlomiej Henryk Noszczyk, Ewa Sawicka, Krystyna Domanska-Janik and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03676569 (Intrathecal Autologous Adipose Derived Regenerative Cells Treatment of Autoimmune Determined Refractory Epilepsy - Evaluation of Safety and Efficacy), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03676569 phase1completednot on this map

Intrathecal Autologous Adipose Derived Regenerative Cells Treatment of Autoimmune Determined Refractory Epilepsy - Evaluation of Safety and Efficacy

TypeinterventionalSponsorMossakowski Medical Research Centre Polish Academy of SciencesRan2015 to 2019Enrolled6ConditionsRefractory EpilepsyArmsADRC transplantation in autoimmune refractory epilepsy
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Stem Cell Therapy in Treating Epilepsy.Frontiers in neuroscience · 2022
    Review
  11. Gene and Cell Therapy for Epilepsy: A Mini Review.Frontiers in molecular neuroscience · 2022
    Review
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Elzbieta SzczepanikClinic of Child and Adolescent Neurology, Institute of Mother and Child, Poland.
Hanna MierzewskaClinic of Child and Adolescent Neurology, Institute of Mother and Child, Poland.
Dorota Antczak-MarachClinic of Child and Adolescent Neurology, Institute of Mother and Child, Poland.
Anna Figiel-DabrowskaMossakowski Medical Research Centre, Polish Academy of Sciences, Poland.
Iwona TerczynskaClinic of Child and Adolescent Neurology, Institute of Mother and Child, Poland.
Jolanta TryfonClinic of Child and Adolescent Neurology, Institute of Mother and Child, Poland.
Natalia KrzesniakDepartment of Plastic Surgery Centre of Postgraduate Medical Education, Poland.
Bartlomiej Henryk NoszczykDepartment of Plastic Surgery Centre of Postgraduate Medical Education, Poland.
Ewa SawickaClinic of Child and Adolescent Surgery, Institute of Mother and Child, Poland.
Krystyna Domanska-JanikMossakowski Medical Research Centre, Polish Academy of Sciences, Poland.ORCID https://orcid.org/0000-0003-0514-7776
Anna SarnowskaMossakowski Medical Research Centre, Polish Academy of Sciences, Poland.ORCID https://orcid.org/0000-0001-6974-8592
Mossakowski Medical Research Institute, Polish Academy of Sciences · PLPostgraduate School of Molecular Medicine · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

methodIntrathecal injection of autologous ADRC acquired through liposuction followed by enzymatic isolation was performed. The procedure was repeated 3 times every 3 months with each patient. Neurological status, brain MRI, cognitive function, and antiepileptic effect were monitored during 12 months.

resultsImmediately after the procedure, all patients were in good condition. In some cases, transient mildly elevated body temperature, pain in regions of liposuction, and slight increasing number of seizures during 24 hours were observed. During the next months, some improvements in school, social functioning, and manual performance were observed in all patients. One patient has been seizure free up to the end of trial. In other patients, frequency of seizures was different: from reduced number to the lack of improvement (3-year follow-up).

conclusionAutologous ADRC therapy may emerge as a promising option for some patients with autoimmune refractory epilepsy. Based on our trial and other clinical data, the therapy appears to be safe and feasible. Antiepileptic efficacy proved to be various; however, some abilities improved in all children. No signs of psychomotor regression were observed during the first year following the treatment.

Identifiers

PMID32190059
PMCPMC7066423
OpenAlexW2997044136

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.