ArticleScientific reports2020
The risk of atrial fibrillation in patients with non-alcoholic fatty liver disease and a high hepatic fibrosis index.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Liver fibrosis burden and risk of incident arrhythmia in metabolic dysfunction-associated steatotic liver disease.Scientific reports · 2026Article
- Fibrosis-4 Index as a Marker of Systemic Fibrotic Burden and Its Association with Left Atrial Thrombus in Nonvalvular Paroxysmal Atrial Fibrillation.Journal of clinical medicine · 2026Article
- Paroxysmal Atrial Fibrillation in Liver Diseases: Epidemiology and Possible Pathophysiological Mechanisms.Journal of clinical medicine · 2026Article
- Metabolic-dysfunction associated steatotic liver disease and atrial fibrillation: A review of pathogenesis.World journal of cardiology · 2025Review
- Metabolic dysfunction associated steatotic liver disease is associated with atrial fibrillation recurrence following cryoballoon ablation.Scientific reports · 2025Article
- Sudden cardiac death associated with fatty liver disease.International journal of cardiology. Heart & vasculature · 2025Article
- An investigation of the association between atrial fibrillation and the liver fibrosis-4 index in patients who underwent coronary computed tomography angiography.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- A Mendelian randomization study reveals a causal association between NASH and the risk of atrial fibrillation.Frontiers in endocrinology · 2025Article
- Inflammation in liver fibrosis and atrial fibrillation: A prospective population-based proteomic study.JHEP reports : innovation in hepatology · 2024Article
- Association of nonalcoholic fatty liver disease with new-onset atrial fibrillation stratified by age groups.Cardiovascular diabetology · 2024Article
- Non-alcoholic fatty liver modifies associations of body mass index and waist circumference with cardiometabolic risk: The CARDIA study.Obesity science & practice · 2024Article
- Review
- Risk Factors Associated With Atrial Fibrillation in Elderly Patients.Journal of clinical medicine research · 2023Article
- Editorial: Interactions between NAFLD and cardiac conduction, structure and function: recent advances and treatments.Frontiers in endocrinology · 2023Article
- Liver fibrosis scores and atrial fibrillation incidence in heart failure with preserved ejection fraction.ESC heart failure · 2022Article
- Liver Fibrosis-4 index indicates atrial fibrillation in acute ischemic stroke.European journal of neurology · 2022Article
- Clinical significance of increased arterial stiffness associated with atrial fibrillation, according to Framingham risk score.Scientific reports · 2021Article
- Article
- Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19.The Journal of infectious diseases · 2020Observational
- Assessing Safety of Anticoagulation for Atrial Fibrillation in Patients with Cirrhosis: A Real-World Outcomes Study.Journal of cardiovascular pharmacology and therapeuticsArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous epidemiological studies focusing on the association between liver disease and atrial fibrillation (AF) show interesting but inconsistent findings. Patients with liver disease have a higher AF risk; however, it is unknown whether the liver fibrosis index can predict AF risk. The medical records of a healthy population undergoing routine health examinations at Healthcare System Gangnam Center, Seoul National University Hospital, were reviewed retrospectively. After excluding subjects with a history of liver disease and known cardiovascular disease, 74,946 subjects with nonalcoholic fatty liver disease (NAFLD) were evaluated. The mean age was 51 ± 11 years, and 71.9% were male. AF was found in 380 (0.5%) subjects. Using univariate analyses, age, male sex, body mass index, hypertension, and diabetes were significantly associated with AF. The fibrosis 4 index (FIB 4) showed significant correlations with AF [unadjusted odds ratio (OR) 3.062 and 95% confidence interval (CI) 2.605-3.600, p = 0.000; adjusted OR 2.255 and 95% CI 1.744-2.915, p = 0.000, with cardiometabolic risk factors adjusted]. In conclusion, NAFLD subjects with higher FIB 4 were associated with increased AF risk. The noninvasive determination of liver fibrosis indices can have clinical implications on the early identification of NAFLD in patients at risk for AF.
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