Evidence map›Paper›PMID 32193573›Full record

SynthesisDiabetologia2020

A core outcome set for studies of gestational diabetes mellitus prevention and treatment.

Aoife M Egan, Delia Bogdanet, Tomás P Griffin, Oratile Kgosidialwa, Mila Cervar-Zivkovic, Eugene Dempsey, John Allotey, Fernanda Alvarado, Cheril Clarson, Shamil D Cooray and 14 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Prediction Models for Maternal and Offspring Short- and Long-Term Outcomes Following Gestational Diabetes: A Systematic Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
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  10. Trial
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  12. Article
  13. Implementation of a Gestational Diabetes Virtual Care Clinic: A Before-After Comparative Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Article
  14. Maternal and neonatal outcomes with different screening strategies for gestational diabetes mellitus: a retrospective cohort study.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025
    Article
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  19. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Aoife M EganDivision of Endocrinology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. egan.aoife@mayo.edu.ORCID 0000-0003-0379-9279
Delia BogdanetSchool of Medicine, National University of Ireland Galway, Galway, Ireland.ORCID 0000-0001-6127-5049
Tomás P GriffinSchool of Medicine, National University of Ireland Galway, Galway, Ireland.ORCID 0000-0003-1625-9394
Oratile KgosidialwaSchool of Medicine, National University of Ireland Galway, Galway, Ireland.ORCID 0000-0002-4249-6302
Mila Cervar-ZivkovicDivision of Obstetrics, Medizinische Universitat Graz, Graz, Austria.
Eugene DempseyINFANT Centre and Department of Paediatrics & Child Health, University College Cork, Cork, Ireland.ORCID 0000-0002-6266-3462
John AlloteyBarts Research Centre for Women's Health (BARC), Women's Health Research Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0003-4134-6246
Fernanda AlvaradoMother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.ORCID 0000-0002-2195-3228
Cheril ClarsonDepartment of Pediatrics, University of Western Ontario, London, ON, Canada.ORCID 0000-0003-0553-6915
Shamil D CoorayBarts Research Centre for Women's Health (BARC), Women's Health Research Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-6825-4440
Harold W de ValkDepartment of Internal Medicine, University Medical Centre Utrecht, Utrecht, the Netherlands.
Sander GaljaardDepartment of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre Rotterdam, 's-Gravendijkwal 230, 3015 CE, Rotterdam, the Netherlands. s.galjaard@erasmusmc.nl.ORCID 0000-0002-4254-6664
Mary R LoekenSection of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-8056-9816
Michael J A MareshDepartment of Obstetrics, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Angela NapoliDepartment of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza, University of Rome, Rome, Italy.ORCID 0000-0002-9750-3944
Paula M O'SheaSchool of Medicine, National University of Ireland Galway, Galway, Ireland.ORCID 0000-0001-9392-1711
Ewa Wender-OzegowskaDepartment of Reproduction, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0002-5492-8651
Mireille N M van PoppelInstitute of Sport Science, University of Graz, Graz, Austria.ORCID 0000-0001-5694-4324
Shakila ThangaratinamBarts Research Centre for Women's Health (BARC), Women's Health Research Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Caroline CrowtherLiggins Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-9079-4451
Linda M BiestySchool of Nursing and Midwifery, National University of Ireland Galway, Galway, Ireland.ORCID 0000-0002-1108-1518
Declan DevaneINFANT Centre and Department of Paediatrics & Child Health, University College Cork, Cork, Ireland.ORCID 0000-0002-9393-7075
Fidelma P DunneSchool of Medicine, National University of Ireland Galway, Galway, Ireland.ORCID 0000-0003-3682-9403
INSPIRED research group

Funding

PILOT STUDY--SECRETORY TARGETING IN PANCREATIC B CELLSP30DK036836 · JOSLIN DIABETES CENTER · 1986 to 2025
$12.1M
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK104649
6 · The paper itself

Abstract

aims/hypothesisThe aim of this systematic review was to develop core outcome sets (COSs) for trials evaluating interventions for the prevention or treatment of gestational diabetes mellitus (GDM).

methodsWe identified previously reported outcomes through a systematic review of the literature. These outcomes were presented to key stakeholders (including patient representatives, researchers and clinicians) for prioritisation using a three-round, e-Delphi study. A priori consensus criteria informed which outcomes were brought forward for discussion at a face-to-face consensus meeting where the COS was finalised.

resultsOur review identified 74 GDM prevention and 116 GDM treatment outcomes, which were presented to stakeholders in round 1 of the e-Delphi study. Round 1 was completed by 173 stakeholders, 70% (121/173) of whom went on to complete round 2; 84% (102/121) of round 2 responders completed round 3. Twenty-two GDM prevention outcomes and 30 GDM treatment outcomes were discussed at the consensus meeting. Owing to significant overlap between included prevention and treatment outcomes, consensus meeting stakeholders agreed to develop a single prevention/treatment COS. Fourteen outcomes were included in the final COS. These consisted of six maternal outcomes (GDM diagnosis, adherence to the intervention, hypertensive disorders of pregnancy, requirement and type of pharmacological therapy for hyperglycaemia, gestational weight gain and mode of birth) and eight neonatal outcomes (birthweight, large for gestational age, small for gestational age, gestational age at birth, preterm birth, neonatal hypoglycaemia, neonatal death and stillbirth). CONCLUSIONS/

interpretationThis COS will enable future GDM prevention and treatment trials to measure similar outcomes that matter to stakeholders and facilitate comparison and combination of these studies.

trial registrationThis study was registered prospectively with the Core Outcome Measures in Effectiveness Trials (COMET) database: http://www.comet-initiative.org/studies/details/686/.

Indexed as

Birth WeightDiabetes, GestationalFemaleHumansInfant, NewbornPregnancyPremature BirthTreatment OutcomeClinical diabetesCore outcome setInsulin therapyPregnancySystematic review

Identifiers

PMID32193573
PMCPMC7228989

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.