Evidence map›Paper›PMID 32195622›Full record

ReviewChannels (Austin, Tex.)2020

The quest to identify the mechanism underlying adrenergic regulation of cardiac Ca

Daniel Roybal, Jessica A Hennessey, Steven O Marx

Open access · goldAbstract readReview
In one paragraph

Review in Channels (Austin, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Convergent regulation of CaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Article
  6. Review
  7. Reconstitution of β-adrenergic regulation of CaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Daniel RoybalDivision of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, USA.ORCID 0000-0003-4153-1564
Jessica A HennesseyDivision of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, USA.ORCID 0000-0002-0733-2433
Steven O MarxDivision of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, USA.ORCID 0000-0002-0577-6030
Columbia College · CAColumbia University · US

Funding

POSTDOCTORAL TRAINING IN CARDIOVASCULAR DISEASET32HL007854 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Marwah Abdalla, Michael Argenziano · 1996 to 2026
$14.7M
L-type channel trafficking and modulation in heartR01HL121253 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Henry M. Colecraft, Steven O Marx · 2014 to 2026
$8.4M
Exploring the Molecular Physiology of Atrial FibrillationR01HL140934 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, MARX, STEVEN O · 2018 to 2025
$6.0M
Phosphorylation-dependent regulation of calcium channels by macromolecular complexesR01HL146149 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven O Marx, Geoffrey S Pitt · 2019 to 2026
$5.0M
Investigation of calcium modulation in cardiomyocytes by novel methodsR01HL113136 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARX, STEVEN O, PITT, GEOFFREY S · 2013 to 2016
$2.2M
Multidisciplinary Research Training in Cardiovascular DiseaseT32HL160520 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Geoffrey S Pitt, Jonathan W. Weinsaft · 2022 to 2026
$2.0M
Signaling Pathways and Regulators of Calcium Channels in HeartF31HL142178 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROYBAL, DANIEL DENNIS · 2019 to 2021
$127k
NHLBI NIH HHS F31 HL142178NHLBI NIH HHS R01 HL113136NHLBI NIH HHS R01 HL121253NHLBI NIH HHS R01 HL146149NHLBI NIH HHS T32 HL007854NHLBI NIH HHS T32 HL160520
6 · The paper itself

Abstract

Activation of protein kinase A by cyclic AMP results in a multi-fold upregulation of Ca

Indexed as

AnimalsCalcium Channels, L-TypeCyclic AMPCyclic AMP-Dependent Protein KinasesHumansModels, BiologicalMyocardiumPhosphorylationCalcium Channels, L-TypeCyclic AMPCyclic AMP-Dependent Protein KinasesL-type calcium channel alpha(1C)adrenergic regulationCalcium channelheartphosphorylationprotein kinase A

Identifiers

PMID32195622
PMCPMC7153787
OpenAlexW3012486483

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.