ArticleAnesthesiology2020
Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan's Experience.
Article in Anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04344561 (UPright Incline Positioning in COVID-19 Patients for Oxygen SATuration Improvement With Hypoxemic Respiratory Failure), which is not on this map. Cited by 300 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
UPright Incline Positioning in COVID-19 Patients for Oxygen SATuration Improvement With Hypoxemic Respiratory Failure (UPSAT)
Who cites it
300 citing papers in PubMed, 4 syntheses or guidelines pooled it, 585 citations in OpenAlex.
- Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Pooled it
- Intubation rate of patients with hypoxia due to COVID-19 treated with awake proning: A meta-analysis.The American journal of emergency medicine · 2021Pooled it
- A systematic review of CT chest in COVID-19 diagnosis and its potential application in a surgical setting.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2020Pooled it
- Use of powered air-purifying respirator (PAPR) by healthcare workers for preventing highly infectious viral diseases-a systematic review of evidence.Systematic reviews · 2020Pooled it
- A hood shield reduces postdoffing contamination during simulated COVID-19 airway management: an exploratory, simulation-based randomized study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Trial
- Application of a protective sleeve is associated with decreased occupational anxiety during endotracheal intubation: a randomized controlled trial.BMC anesthesiology · 2021Trial
- Trial
- Impact of aerosol box on intubation during COVID-19: a simulation study of normal and difficult airways.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Trial
- Promising effects of tocilizumab in COVID-19: A non-controlled, prospective clinical trial.International immunopharmacology · 2020Trial
- Larynx Injuries After Orotracheal Intubation: What are Risk Factors Observed in Patients with Covid?International archives of otorhinolaryngology · 2026Article
- Invasive ventilator exhaust in critical care: aerosol transmission risks and management strategies-a narrative review.Critical care (London, England) · 2025Review
- The Effect of Prehospital Protocol Modification during COVID-19 on First-Pass Intubation Success Rates.Prehospital and disaster medicine · 2025Article
- Pharmacokinetics of Enteral Lormetazepam in Mechanically Ventilated ICU Patients with COVID-19: An Adjunct Sedative Study.Clinical pharmacokinetics · 2024Article
- COVID-19 Recovery Time and Its Predictors among Hospitalized Patients in Designated Hospitals in the Madhesh Province of Nepal: A Multicentric Study.Healthcare (Basel, Switzerland) · 2024Article
- Comparison of Three Tracheal Intubation Procedures Using Personal Protective Equipment, Direct and Video Laryngoscopes: An Open, Randomized, Parallel Clinical Trial.Anesthesiology and pain medicine · 2024Article
- A randomised clinical trial of awake prone positioning in COVID-19 suspects with acute hypoxemic respiratory failure.Contemporary clinical trials communications · 2024Article
- ROX Index Variation as a Predictor of Outcomes in COVID-19 Patients.Journal of clinical medicine · 2024Article
- Worse survival in patients with right ventricular dysfunction and COVID-19-associated acute respiratory distress requiring extracorporeal membrane oxygenation: A multicenter study from the ORACLE Group.The Journal of thoracic and cardiovascular surgery · 2024Article
- Comparison between high-flow nasal oxygen (HFNO) alternated with non-invasive ventilation (NIV) and HFNO and NIV alone in patients with COVID-19: a retrospective cohort study.European journal of medical research · 2024Article
- Article
240 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
The COVID-19 outbreak has led to 80,409 diagnosed cases and 3,012 deaths in mainland China based on the data released on March 4, 2020. Approximately 3.2% of patients with COVID-19 required intubation and invasive ventilation at some point in the disease course. Providing best practices regarding intubation and ventilation for an overwhelming number of patients with COVID-19 amid an enhanced risk of cross-infection is a daunting undertaking. The authors presented the experience of caring for the critically ill patients with COVID-19 in Wuhan. It is extremely important to follow strict self-protection precautions. Timely, but not premature, intubation is crucial to counter a progressively enlarging oxygen debt despite high-flow oxygen therapy and bilevel positive airway pressure ventilation. Thorough preparation, satisfactory preoxygenation, modified rapid sequence induction, and rapid intubation using a video laryngoscope are widely used intubation strategies in Wuhan. Lung-protective ventilation, prone position ventilation, and adequate sedation and analgesia are essential components of ventilation management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.