Evidence map›Paper›PMID 32196851›Full record

ArticleJournal of biochemical and molecular toxicology2020

Resveratrol for protection against statin toxicity in C2C12 and H9c2 cells.

Chama Attalah Nee Rezkallah, Angkana Thongkum, Chao Zhu, Qin M Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biochemical and molecular toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pleiotropic use of Statins as non-lipid-lowering drugs.International journal of biological sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chama Attalah Nee RezkallahDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Angkana ThongkumDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Chao ZhuDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.
Qin M ChenDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona.ORCID http://orcid.org/0000-0002-2409-7463
University of Arizona · US

Funding

Nrf2 Protein Translation for Protection Against Tissue InjuryR01GM126165 · NIGMS · UNIVERSITY OF ARIZONA · PI CHEN, QIN M · 2018 to 2021
$1.7M
Mechanism and Function of Stress Induced Protein TranslationR01GM125212 · NIGMS · UNIVERSITY OF ARIZONA · PI CHEN, QIN M · 2018 to 2021
$1.4M
Translation Control of Oxidative StressR01GM111337 · NIGMS · UNIVERSITY OF ARIZONA · PI CHEN, QIN M · 2014 to 2016
$803k
National Institute of Health R01 GM125212A1National Institute of Health R01 GM126165A1NIGMS NIH HHS R01 GM111337NIGMS NIH HHS R01 GM125212NIGMS NIH HHS R01 GM126165
6 · The paper itself

Abstract

Statins are among the most commonly prescribed drugs for the treatment of high blood cholesterol. Myotoxicity of statins in certain individuals is often a severe side effect leading to withdrawal. Using C2C12 and H9c2 cells, both exhibiting characteristics of skeletal muscle cells, we addressed whether resveratrol (RSV) can prevent statin toxicity. Statins decreased cell viability in a dose and time-dependent manner. Among the five statins tested, atorvastatin, simvastatin, lovastatin, pravastatin, and fluvastatin, simvastatin is the most toxic one. Simvastatin at 10 µM caused about 65% loss of metabolic activity as measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays in C2C12 cells or H9c2 cells. Inhibition of metabolic activity correlates with an increase in caspase activity. RSV was found to protect H9c2 cells from simvastatin-induced activation of caspase-3/7. However, such protection was not found in C2C12 cells. This cell type-dependent effect of RSV adds to the complexity in muscle cell toxicity of statins.

Indexed as

AnimalsAtorvastatinCaspase 3Caspase 7Cell LineCell SurvivalFluvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsLovastatinMiceMyoblastsPravastatinProtective AgentsRatsResveratrolSignal TransductionAtorvastatinCasp3 protein, ratCasp7 protein, ratCaspase 3Caspase 7FluvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsLovastatinPravastatinProtective AgentsResveratrolSimvastatincytotoxicitylipid-lowering drugmetabolic inhibitionnutritional supplement

Identifiers

PMID32196851
PMCPMC8827215
OpenAlexW3012378013

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.