ReviewJournal of molecular biology2020
The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks.
Review in Journal of molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- The effect of wet cupping therapy on the clinical symptoms of adult-onset asthma: a randomized clinical trial.Turkish journal of medical sciences · 2024Trial
- The phenology of the European flat oyster (Ostrea edulis) and its environmental drivers.Scientific reports · 2026Article
- Genomic insights into marine-freshwater transition: evolutionary adaptations in freshwater Pusa seals.Genetica · 2026Article
- Evolutionary and physiological arguments for the existence of a circalunar clock in humans.BMC ecology and evolution · 2026Review
- The Association Between Lunar Phases and Calving Frequency in Montbéliarde Dairy Cows in the Franche-Comté Region, France.Animals : an open access journal from MDPI · 2026Article
- Photoreceptor control ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Waning light, waxing pain: The lunar cycle's association with migraine headache occurrence.Headache · 2026Article
- An Autonomous Clock that Controls Genetic Information Flow and Cellular Proteostasis.Advances in experimental medicine and biology · 2026Review
- Synchronization of women's menstruation with the Moon has decreased but remains detectable when gravitational pull is strong.Science advances · 2025Article
- Autoactivation of the HeLa 9903 test system during a full moon.Cytotechnology · 2025Article
- Composition and rhythmic variations in the microbiome of Southwestern Atlantic corals.Environmental microbiome · 2025Article
- Lunar cycle and moonlight intensity influence nocturnal migration patterns in a small songbird.Scientific reports · 2025Article
- Darkening of the Global Ocean.Global change biology · 2025Article
- Association between the lunar cycle and pregnancy at first artificial insemination of Holstein cows.JDS communications · 2025Article
- Characterization of the daily and circadian valve behavior of the European flat oyster Ostrea edulis.Scientific reports · 2025Article
- Quantum food and nutrition: Subatomic approaches to nourishment for health and well-being.Asia Pacific journal of clinical nutrition · 2025Article
- Redefining the photic zone: beyond the autotroph-centric view of light in the ocean.Communications earth & environment · 2025Review
- Effect of lunar phases on international normalized ratio in patients with deep vein thrombosis using warfarin.Journal of education and health promotion · 2025Article
- Lemming and Vole Cycles: A New Intrinsic Model.Ecology and evolution · 2024Review
- Chronobiotic and cytoprotective activity of melatonin in the cardiovascular system. Doses matter.Npj biological timing and sleep · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Starting with the beginning of the last century, a multitude of scientific studies has documented that the lunar cycle times behaviors and physiology in many organisms. It is plausible that even the first life forms adapted to the different rhythms controlled by the moon. Consistently, many marine species exhibit lunar rhythms, and also the number of documented "lunar-rhythmic" terrestrial species is increasing. Organisms follow diverse lunar geophysical/astronomical rhythms, which differ significantly in terms of period length: from hours (circalunidian and circatidal rhythms) to days (circasemilunar and circalunar cycles). Evidence for internal circatital and circalunar oscillators exists for a range of species based on past behavioral studies, but those species with well-documented behaviorally free-running lunar rhythms are not typically used for molecular studies. Thus, the underlying molecular mechanisms are largely obscure: the dark side of the moon. Here we review findings that start to connect molecular pathways with moon-controlled physiology and behaviors. The present data indicate connections between metabolic/endocrine pathways and moon-controlled rhythms, as well as interactions between circadian and circatidal/circalunar rhythms. Moreover, recent high-throughput analyses provide useful leads toward pathways, as well as molecular markers. However, for each interpretation, it is important to carefully consider the, partly substantially differing, conditions used in each experimental paradigm. In the future, it will be important to use lab experiments to delineate the specific mechanisms of the different solar- and lunar-controlled rhythms, but to also start integrating them together, as life has evolved equally long under rhythms of both sun and moon.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.