Evidence map›Paper›PMID 32200719›Full record

ArticleJournal of the American Heart Association2020

Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of

Shungang Zhang, Joshua D Breidenbach, Fatimah K Khalaf, Prabhatchandra R Dube, Chrysan J Mohammed, Apurva Lad, Stanislaw Stepkowski, Terry D Hinds, Sivarajan Kumarasamy, Andrew Kleinhenz and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Paraoxonases at the Heart of Neurological Disorders.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Shungang ZhangDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
Joshua D BreidenbachDepartment of Medical Microbiology and Immunology University of Toledo College of Medicine and Life Sciences Toledo OH.
Fatimah K KhalafDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
Prabhatchandra R DubeDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
Chrysan J MohammedDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
Apurva LadDepartment of Medical Microbiology and Immunology University of Toledo College of Medicine and Life Sciences Toledo OH.
Stanislaw StepkowskiDepartment of Medical Microbiology and Immunology University of Toledo College of Medicine and Life Sciences Toledo OH.
Terry D HindsDepartment of Physiology and Pharmacology University of Toledo College of Medicine and Life Sciences Toledo OH.
Sivarajan KumarasamyDepartment of Physiology and Pharmacology University of Toledo College of Medicine and Life Sciences Toledo OH.
Andrew KleinhenzDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
Jiang TianDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
Deepak MalhotraDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
David J KennedyDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
Christopher J CooperDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
Steven T HallerDepartment of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.
University of Toledo · USUniversity of Toledo Medical Center · US

Funding

Counter regulatory mechanisms of cardiotonic steroids in cardio-renal syndromeR01HL137004 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI KENNEDY, DAVID JOSEPH · 2017 to 2021
$1.9M
Na/K-ATPase Reduction in Renal Disease-Related Cardiac DysfunctionR01HL105649 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI TIAN, JIANG · 2012 to 2016
$1.8M
NHLBI NIH HHS R01 HL105649NHLBI NIH HHS R01 HL137004
6 · The paper itself

Abstract

Background Renal artery stenosis is a common cause of renal ischemia, contributing to the development of chronic kidney disease. To investigate the role of local CD40 expression in renal artery stenosis, Goldblatt 2-kidney 1-clip surgery was performed on hypertensive Dahl salt-sensitive rats (S rats) and genetically modified S rats in which CD40 function is abolished (

Indexed as

MutationAnimalsBlood PressureCD40 AntigensCell LineDisease Models, AnimalFibrosisGlomerular Filtration RateHumansInflammation MediatorsIschemiaKidneyKidney Tubules, ProximalMaleOxidative StressPlasminogen Activator Inhibitor 1CD40 AntigensInflammation MediatorsPlasminogen Activator Inhibitor 1Serpine1 protein, ratCD40renal fibrosisrenal ischemia

Identifiers

PMID32200719
PMCPMC7428653
OpenAlexW3012900710

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.