Evidence map›Paper›PMID 32205413›Full record

ReviewCold Spring Harbor perspectives in medicine2021

T-Cell Immunity against the Hepatitis C Virus: A Persistent Research Priority in an Era of Highly Effective Therapy.

Stephanie Smith, Jonathan R Honegger, Christopher Walker

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Human hepatitis D virus-specific T cell epitopes.JHEP reports : innovation in hepatology · 2021
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Stephanie SmithThe Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, Ohio 43205, USA.
Jonathan R HoneggerThe Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, Ohio 43205, USA.
Christopher WalkerThe Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's, Columbus, Ohio 43205, USA.
The Ohio State University · USNationwide Children's Hospital · US

Funding

Persistent hepatitis C virus replication and T cell immunity in pregnancyR01AI096882 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WALKER, CHRISTOPHER M. · 2012 to 2022
$5.7M
T cell Immunity and the Outcome of Acute HCV InfectionR01AI126890 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GRAKOUI, ARASH, WALKER, CHRISTOPHER M. · 2016 to 2020
$3.7M
T Cell Immunity and HCV Infection OutcomeU01AI131313 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WALKER, CHRISTOPHER M. · 2016 to 2020
$1.3M
NIAID NIH HHS R01 AI096882NIAID NIH HHS R01 AI126890NIAID NIH HHS U01 AI131313
6 · The paper itself

Abstract

Approximately 70% of acute hepatitis C virus (HCV) infections become chronic, indicating that the virus is exceptionally well adapted to persist in humans with otherwise normal immune function. Robust, lifelong replication of this small RNA virus does not require a generalized failure of immunity. HCV effectively subverts innate and adaptive host defenses while leaving immunity against other viruses intact. Here, the role of CD4

Indexed as

AnimalsAntiviral AgentsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHepacivirusHepatitis C, ChronicHumansRecurrenceResearchAntiviral Agents

Identifiers

PMID32205413
PMCPMC7778213
OpenAlexW3012869203

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.