Evidence map›Paper›PMID 32205447›Full record

ArticleThe Journal of biological chemistry2020

5-Ethynyl-2'-deoxycytidine and 5-ethynyl-2'-deoxyuridine are differentially incorporated in cells infected with HSV-1, HCMV, and KSHV viruses.

Salomé Manska, Rionna Octaviano, Cyprian C Rossetto

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Salomé ManskaDepartment of Microbiology and Immunology, University of Nevada, Reno, School of Medicine, Reno, Nevada 89557.
Rionna OctavianoDepartment of Microbiology and Immunology, University of Nevada, Reno, School of Medicine, Reno, Nevada 89557.
Cyprian C RossettoDepartment of Microbiology and Immunology, University of Nevada, Reno, School of Medicine, Reno, Nevada 89557. Electronic address: crossetto@med.unr.edu.
University of Nevada, Reno · US

Funding

Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Eduardo A Robleto · 2012 to 2026
$58.0M
CHARACTERIZATION OF HCMV UL84R01AI045096 · NIAID · UNIVERSITY OF NEVADA RENO · PI ROSSETTO, CYPRIAN CONSTANCE · 2000 to 2014
$4.6M
Elucidation of HCMV latent viral genome maintenance/replication factorsR56AI106737 · NIAID · UNIVERSITY OF NEVADA RENO · PI ROSSETTO, CYPRIAN CONSTANCE · 2014 to 2014
$393k
NIAID NIH HHS R01 AI045096NIAID NIH HHS R56 AI106737NIGMS NIH HHS P20 GM103440
6 · The paper itself

Abstract

Nucleoside analogues are a valuable experimental tool. Incorporation of these molecules into newly synthesized DNA (

Indexed as

Biological TransportCell LineCytomegalovirusDeoxycytidineDeoxyuridineFibroblastsHerpesvirus 1, HumanHerpesvirus 8, HumanHumansRetinal Pigment Epithelium5-ethynyl-2'-deoxycytidine5-ethynyl-2'-deoxyuridineDeoxycytidineDeoxyuridine5-ethynyl-2′-deoxycytidine (EdC)5-ethynyl-2′-deoxyuridine (EdU)cell proliferationDNA replicationfluorescent reporterherpesvirusnon-radioactive labelingnucleoside/nucleotide analoguenucleoside/nucleotide metabolismpulse labelingthymidine kinaseviral replication

Identifiers

PMID32205447
PMCPMC7196651
OpenAlexW3012650760

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.