ArticleHuman molecular genetics2020
Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases.
Article in Human molecular genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting.Journal of translational medicine · 2022Pooled it
- Polygenic risk scores for cardiovascular disease: clinical utility and limitations.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026Review
- The Predictive Value of Hemoglobin Glycation Index and Clonal Hematopoiesis of Indeterminate Potential Among AMI Patients-A Prospective Registry Study.Journal of diabetes · 2026Article
- Article
- Estimating Causal Effects on a Disease Progression Trait Using Bivariate Mendelian Randomisation.Genetic epidemiology · 2025Article
- Polygenic Risk and Coronary Artery Disease Severity.Circulation. Genomic and precision medicine · 2024Article
- Polygenic Risk Scores: The Next Step for Improved Risk Stratification in Coronary Artery Disease?Arquivos brasileiros de cardiologia · 2024Review
- Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection.Journal of translational medicine · 2024Article
- Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study.European heart journal · 2023Article
- A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.Nature medicine · 2023Article
- Genetics of diabetes.World journal of diabetes · 2023Review
- The necessity of incorporating non-genetic risk factors into polygenic risk score models.Scientific reports · 2023Article
- Strategies to investigate and mitigate collider bias in genetic and Mendelian randomisation studies of disease progression.PLoS genetics · 2023Review
- Predictive capacity of a genetic risk score for coronary artery disease in assessing recurrences and cardiovascular mortality among patients with myocardial infarction.Frontiers in cardiovascular medicine · 2023Article
- Article
- Interpreting Mendelian-randomization estimates of the effects of categorical exposures such as disease status and educational attainment.International journal of epidemiology · 2022Article
- Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer.Cancer causes & control : CCC · 2022Article
- American Heart Association's Life's Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease.Circulation · 2022Article
- Considering strategies for SNP selection in genetic and polygenic risk scores.Frontiers in genetics · 2022Article
- Vascular smooth muscle cells in atherosclerosis: time for a re-assessment.Cardiovascular research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThere is growing evidence that polygenic risk scores (PRSs) can identify individuals with elevated lifetime risk of coronary artery disease (CAD). Whether they can also be used to stratify the risk of subsequent events among those surviving a first CAD event remain uncertain, with possible biological differences between CAD onset and progression, and the potential for index event bias.
methodsUsing two baseline subsamples of UK Biobank: prevalent CAD cases (N = 10 287) and individuals without CAD (N = 393 108), we evaluated associations between a CAD PRS and incident cardiovascular and fatal outcomes.
resultsA 1 SD higher PRS was associated with an increased risk of incident myocardial infarction (MI) in participants without CAD (OR 1.33; 95% CI 1.29, 1.38), but the effect estimate was markedly attenuated in those with prevalent CAD (OR 1.15; 95% CI 1.06, 1.25) and heterogeneity P = 0.0012. Additionally, among prevalent CAD cases, we found an evidence of an inverse association between the CAD PRS and risk of all-cause death (OR 0.91; 95% CI 0.85, 0.98) compared with those without CAD (OR 1.01; 95% CI 0.99, 1.03) and heterogeneity P = 0.0041. A similar inverse association was found for ischaemic stroke [prevalent CAD (OR 0.78; 95% CI 0.67, 0.90); without CAD (OR 1.09; 95% CI 1.04, 1.15), heterogeneity P < 0.001].
conclusionsBias induced by case stratification and survival into UK Biobank may distort the associations of PRS derived from case-control studies or populations initially free of disease. Differentiating between effects of possible biases and genuine biological heterogeneity is a major challenge in disease progression research.
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