ArticleJournal of the American Heart Association2020
Cardiovascular Disease Burden in Rural Africa: Does HIV and Antiretroviral Treatment Play a Role?: Baseline Analysis of the Ndlovu Cohort Study.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Pooled it
- Pooled it
- HIV and ART status at baseline are associated longitudinally with increased pulse wave velocity: findings from the Ndlovu Cohort Study.AIDS (London, England) · 2026Article
- Experiences and impact of chronic pain in South Africans living in a rural area: a qualitative study.BMJ open · 2025Article
- The association of premature atherosclerosis with ischemic stroke in young people with HIV in Lusaka, Zambia.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Article
- Human immunodeficiency virus and antiretroviral therapies exert distinct influences across diverse gut microbiomes.Nature microbiology · 2025Article
- Occupational Syndemics in Farmworkers in the Cape Winelands, South Africa.Tropical medicine and infectious disease · 2025Article
- The association of HIV status and depressive symptoms in the Ndlovu Cohort study.Scientific reports · 2025Article
- A Comprehensive Review of the Manifestation of Cardiovascular Diseases in HIV Patients.Cureus · 2025Review
- No Evidence for an Association of HIV and Antiviral Treatment With Changes in Framingham Cardiovascular Risk Score in the Ndlovu Cohort Study.Journal of the American Heart Association · 2024Article
- HIV Infection and 90-Day Stroke Outcomes in Uganda: A Prospective Observational Cohort Study.Neurology. Clinical practice · 2023Article
- Pharmacotherapeutic profile, polypharmacy and its associated factors in a cohort of people living with HIV in Brazil.AIDS research and therapy · 2023Article
- Vascular dysfunction and body mass index in African adults with HIV.BMC cardiovascular disorders · 2023Article
- Prevalence and risk factors for subclinical atherosclerosis amongst adults living with HIV in University of Abuja Teaching Hospital, Gwagwalada.Frontiers in reproductive health · 2023Article
- Association between HIV and Prevalent Hypertension and Diabetes Mellitus in South Africa: Analysis of a Nationally Representative Cross-Sectional Survey.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Age-related differences in the vascular function and structure of South Africans living with HIV.Southern African journal of HIV medicine · 2022Review
- Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy.Frontiers in medicine · 2022Article
- The influence of smoking and HIV infection on pulmonary function.Southern African journal of HIV medicine · 2022Article
- A Matter of Fat: Body Fat Distribution and Cardiometabolic Disease in Africa.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Ischemic Heart Disease in Nigeria: Exploring the Challenges, Current Status, and Impact of Lifestyle Interventions on Its Primary Healthcare System.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background HIV is associated with an increased risk of cardiovascular disease (CVD) in high-income countries. Little is known about the CVD burden in sub-Saharan Africa, where 70% of the world's HIV-positive population lives. This study aims to provide insight into the burden of CVD risk in a rural setting in sub-Saharan Africa considering HIV infection and antiretroviral therapy (ART). Methods and Results A cross-sectional analysis was conducted of the baseline of the Ndlovu Cohort study including HIV-negative and HIV-positive participants in rural South Africa between 2014 and 2017. Information was collected on demographics, socioeconomic status, and CVD risk factors. Carotid intima-media thickness measurement was performed. The influence of HIV and ART on the burden of CVD was determined by comparing HIV-positive participants who were ART naive on first-line or second-line ART with HIV-negative participants. In total, 1927 participants were included, of whom 887 (46%) were HIV positive and 54% women. The median age was 38 years. Overall, 690 participants (79%) were on ART, with 613 (89%) on first-line and 77 (11%) on second-line therapy. Participants with HIV had lower values for most of the CVD risk factors but higher C-reactive protein levels than HIV-negative participants. ART-naive, HIV-positive participants had similar carotid intima-media thickness compared with HIV-negative participants but carotid intima-media thickness was increased for participants on ART aged 30 years and older compared with HIV-negative participants. Conclusions HIV-positive participants presented with a favorable CVD risk profile compared with HIV-negative participants. However, carotid intima-media thickness was increased in HIV-positive participants on ART, indicating a higher burden of subclinical CVD for the HIV-positive population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.