Evidence map›Paper›PMID 32226609›Full record

ReviewF1000Research2020

Recent advances in mast cell activation and regulation.

Hwan Soo Kim, Yu Kawakami, Kazumi Kasakura, Toshiaki Kawakami

Abstract readReview
In one paragraph

Review in F1000Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Caffeic Acid Inhibits Degranulation, Cytokine Secretions, andInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation.The journal of allergy and clinical immunology. Global · 2024
    Article
  7. Role of Mast Cells in Eosinophilic Gastrointestinal Diseases.Immunology and allergy clinics of North America · 2024
    Review
  8. Mast cell in infantile hemangioma.Frontiers in oncology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hwan Soo KimDivision of Cell Biology, La Jolla Institute for Immunology, La Jolla, California, 92037, USA.ORCID 0000-0002-5952-7849
Yu KawakamiDivision of Cell Biology, La Jolla Institute for Immunology, La Jolla, California, 92037, USA.
Kazumi KasakuraDivision of Cell Biology, La Jolla Institute for Immunology, La Jolla, California, 92037, USA.
Toshiaki KawakamiDivision of Cell Biology, La Jolla Institute for Immunology, La Jolla, California, 92037, USA.ORCID 0000-0002-0427-1217

Funding

Training in Immunological MechanismsT32AI125179 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2016 to 2025
$3.1M
Histamine-Releasing Factor Oligomers in Food AllergyR01AI146042 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KAWAKAMI, TOSHIAKI · 2019 to 2022
$2.5M
Crosstalk between FceRI and MAVS signaling pathways in mast cellsR21AI153867 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KAWAKAMI, TOSHIAKI · 2020 to 2021
$503k
NIAID NIH HHS R01 AI146042NIAID NIH HHS R21 AI153867NIAID NIH HHS T32 AI125179
6 · The paper itself

Abstract

Mast cells are innate immune cells that intersect with the adaptive immunity and play a crucial role in the initiation of allergic reactions and the host defense against certain parasites and venoms. When activated in an allergen- and immunoglobulin E (IgE)-dependent manner, these cells secrete a large variety of allergenic mediators that are pre-stored in secretory granules or

Indexed as

Mast CellsAllergensAnimalsCytokinesHumansImmunoglobulin ENerve Tissue ProteinsReceptors, G-Protein-CoupledReceptors, NeuropeptideAllergensCytokinesImmunoglobulin EMRGPRX2 protein, humanNerve Tissue ProteinsReceptors, G-Protein-CoupledReceptors, NeuropeptideallergenAllergyFcεRIIgEIL-33mast cellsmiRNAMRGPRX2

Identifiers

PMID32226609
PMCPMC7096214

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.