Evidence map›Paper›PMID 32229578›Full record

ArticleMolecular and cellular biology2020

LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia.

Justin H Layer, Michael Christy, Lindsey Placek, Derya Unutmaz, Yan Guo, Utpal P Davé

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Justin H LayerDivision of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Michael ChristyDivision of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Lindsey PlacekThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Derya UnutmazThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Yan GuoUniversity of New Mexico Cancer Center, Albuquerque, New Mexico, USA.
Utpal P DavéDivision of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA udave@iu.edu.
Indiana University – Purdue University Indianapolis · USJackson Laboratory · USUniversity of New Mexico · US

Funding

Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
The Role of LMO2 in the Pathogenesis of T-cell LeukemiaR01CA207530 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI DAVE, UTPAL P · 2016 to 2020
$1.8M
Pathophysiology of Adult T-cell Leukemia/LymphomaI01BX001799 · VA · VETERANS HEALTH ADMINISTRATION · PI DAVE, UTPAL P · 2013 to 2025
–
BLRD VA I01 BX001799NCI NIH HHS R01 CA207530NIDDK NIH HHS U54 DK106846
6 · The paper itself

Abstract

The LMO2/LDB1 macromolecular complex is critical in hematopoietic stem and progenitor cell specification and in the development of acute leukemia. This complex is comprised of core subunits of LMO2 and LDB1 as well as

Indexed as

Adaptor Proteins, Signal TransducingCell Line, TumorDNA-Binding ProteinsHEK293 CellsHumansLeukemiaLIM Domain ProteinsMitochondrial ProteinsOncogene ProteinsProteasome Endopeptidase ComplexProtein BindingProtein StabilityProteolysisProto-Oncogene ProteinsT-Cell Acute Lymphocytic Leukemia Protein 1Transcription FactorsAdaptor Proteins, Signal TransducingDNA-Binding ProteinsLDB1 protein, humanLIM Domain ProteinsLMO2 protein, humanMitochondrial ProteinsNABP2 protein, humanOncogene ProteinsProteasome Endopeptidase ComplexProto-Oncogene ProteinsTAL1 protein, humanT-Cell Acute Lymphocytic Leukemia Protein 1Transcription FactorsUbiquitinhematopoietic stem cellleukemiaLIM domain Only 2LIM domain protein 1multisubunit complexprotein degradationprotein turnoverpulse-chase

Identifiers

PMID32229578
PMCPMC7261719
OpenAlexW3013778168

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.