Evidence map›Paper›PMID 32229584›Full record

ArticleThe Journal of biological chemistry2020

The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.

Qiang Wang, Taylor A N Henry, Alexey N Pronin, Geeng-Fu Jang, Camila Lubaczeuski, John W Crabb, Ernesto Bernal-Mizrachi, Vladlen Z Slepak

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qiang WangDepartment of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136.
Taylor A N HenryDepartment of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136.
Alexey N ProninDepartment of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136.
Geeng-Fu JangCole Eye Institute and Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Camila LubaczeuskiDivision of Endocrinology, Diabetes, and Metabolism, University of Miami School of Medicine, Miami, Florida 33136.
John W CrabbCole Eye Institute and Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Ernesto Bernal-MizrachiDivision of Endocrinology, Diabetes, and Metabolism, University of Miami School of Medicine, Miami, Florida 33136.
Vladlen Z SlepakDepartment of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136. Electronic address: vslepak@med.miami.edu.
University of Miami · USCleveland Clinic Lerner College of Medicine · US

Funding

RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7M
AKT/mTOR Signaling and Regulation of Cell Cycle in beta CellsR01DK073716 · NIDDK · WASHINGTON UNIVERSITY · PI BERNAL-MIZRACHI, ERNESTO · 2006 to 2022
$4.6M
Nutrient Signals and Programming of Pancreas DevelopmentR01DK084236 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERNAL-MIZRACHI, ERNESTO · 2010 to 2018
$2.9M
Gbeta5-R7 Complex in Signaling and Hormone SecretionR01DK105427 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SLEPAK, VLADLEN Z · 2015 to 2018
$1.8M
Carboxyethylpyrrole-Ethanolamine Phospholipids as AMD BiomarkersR21EY025388 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI CRABB, JOHN W · 2015 to 2016
$436k
Neuronal control of body weight and size by the Gbeta5-R7 signaling complexR56DK119262 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SLEPAK, VLADLEN Z · 2019 to 2019
$192k
BLRD VA I01 BX002728NEI NIH HHS P30 EY025585NEI NIH HHS R21 EY025388NIDDK NIH HHS R01 DK073716NIDDK NIH HHS R01 DK084236NIDDK NIH HHS R01 DK105427NIDDK NIH HHS R56 DK119262
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) are important modulators of glucose-stimulated insulin secretion, essential for maintaining energy homeostasis. Here we investigated the role of Gβ5-R7, a protein complex consisting of the atypical G protein β subunit Gβ5 and a regulator of G protein signaling of the R7 family. Using the mouse insulinoma MIN6 cell line and pancreatic islets, we investigated the effects of G protein subunit β 5 (

Indexed as

Insulin SecretionMAP Kinase Signaling SystemAnimalsCell Line, TumorGlucoseGTP-Binding Protein beta SubunitsInsulin-Secreting CellsMiceMice, KnockoutReceptors, G-Protein-CoupledReceptors, NeuropeptideGlucoseGnb5 protein, mouseGTP-Binding Protein beta SubunitsNpbwr1 protein, mouseReceptors, G-Protein-CoupledReceptors, Neuropeptideactincell adhesionG protein–coupled receptor (GPCR)insulin releasepancreasregulator of G protein signaling (RGS)signal transduction

Identifiers

PMID32229584
PMCPMC7247291
OpenAlexW3013702885

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.