Evidence map›Paper›PMID 32232621›Full record

ReviewCancer metastasis reviews2020

BRMS1: a multifunctional signaling molecule in metastasis.

Rosalyn C Zimmermann, Danny R Welch

Open access · greenAbstract readReview
In one paragraph

Review in Cancer metastasis reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rosalyn C ZimmermannDepartment of Cancer Biology, The Kansas University Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.ORCID https://orcid.org/0000-0001-8611-2545
Danny R WelchDepartment of Cancer Biology, The Kansas University Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA. DWelch@KUMC.edu.ORCID https://orcid.org/0000-0002-1951-4947
University Medical Center · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
MOLECULAR REGULATION OF BREAST CANCER METASTASISR01CA087728 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELCH, DANNY R. · 2000 to 2008
$2.7M
KISS1: Defining Mechanisms for Antimetastatic TherapyR01CA134981 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI WELCH, DANNY R. · 2009 to 2014
$1.5M
NCI NIH HHS P30 CA168524NCI NIH HHS R01 CA087728NCI NIH HHS R01 CA134981NIGMS NIH HHS P20 GM103418
6 · The paper itself

Abstract

Despite high mortality rates, molecular understanding of metastasis remains limited. It can be regulated by both pro- and anti-metastasis genes. The metastasis suppressor, breast cancer metastasis suppressor 1 (BRMS1), has been positively correlated with patient outcomes, but molecular functions are still being characterized. BRMS1 has been implicated in focal adhesion kinase (FAK), epidermal growth factor receptor (EGFR), and NF-κB signaling pathways. We review evidence that BRMS1 regulates these vast signaling pathways through chromatin remodeling as a member of mSin3 histone deacetylase complexes.

Indexed as

AnimalsDisease ProgressionHumansNeoplasm MetastasisNeoplasmsRepressor ProteinsSignal TransductionBRMS1 protein, humanBRMS1 protein, mouseRepressor ProteinsBreast cancer metastasis suppressor 1BRMS1Epigenetic(s)Histone deacetylasemSin3

Identifiers

PMID32232621
PMCPMC7487056
OpenAlexW3013333628

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.