Evidence map›Paper›PMID 32235003›Full record

ArticleAging2020

Genetics of physiological dysregulation: findings from the long life family study using joint models.

Konstantin G Arbeev, Olivia Bagley, Svetlana V Ukraintseva, Deqing Wu, Hongzhe Duan, Alexander M Kulminski, Eric Stallard, Kaare Christensen, Joseph H Lee, Bharat Thyagarajan and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Konstantin G ArbeevBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham NC, 27708, USA.
Olivia BagleyBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham NC, 27708, USA.
Svetlana V UkraintsevaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham NC, 27708, USA.
Deqing WuBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham NC, 27708, USA.
Hongzhe DuanBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham NC, 27708, USA.
Alexander M KulminskiBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham NC, 27708, USA.
Eric StallardBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham NC, 27708, USA.
Kaare ChristensenDanish Aging Research Center, Department of Public Health, University of Southern Denmark 5000, Odense C, Denmark.
Joseph H LeeTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY 10032, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Joseph M ZmudaDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Anatoliy I YashinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham NC, 27708, USA.
Duke University · USSocial Science Research Council · USColumbia University Irving Medical Center · USUniversity of Minnesota · USUniversity of Pittsburgh · USUniversity of Southern Denmark · DK

Funding

The Long Life Family StudyU19AG063893 · NIA · WASHINGTON UNIVERSITY · PI Stacy Andersen, KAARE CHRISTENSEN · 2019 to 2026
$125.4M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SANTA-MARIA PEREZ, ISMAEL · 1989 to 2019
$46.3M
Plasma beta-amyloid in long lived families: genetics and risk of ADU01AG023749 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSENTINO, STEPHANIE ANN, LEE, JOSEPH HYUNGWOO · 2004 to 2018
$13.0M
Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field CenterU01AG023712 · NIA · DUKE UNIVERSITY · PI CHRISTENSEN, KAARE · 2004 to 2018
$10.4M
Relationships among Genetic Regulators of Aging Health and LifespanP01AG043352 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2014 to 2018
$8.7M
Understanding Alzheimer's Disease in the Context of the AgingR01AG062623 · NIA · DUKE UNIVERSITY · PI OUKRAINTSEVA, SVETLANA V. · 2019 to 2023
$3.6M
NIA NIH HHS P01 AG043352NIA NIH HHS P50 AG008702NIA NIH HHS R01 AG062623NIA NIH HHS U01 AG023712NIA NIH HHS U01 AG023749NIA NIH HHS U19 AG063893
6 · The paper itself

Abstract

Recently, Mahalanobis distance (D

Indexed as

AgingNeoplasmsBiomarkersChronobiology PhenomenaFemaleGene Regulatory NetworksGenome-Wide Association StudyGuanine Nucleotide Exchange FactorsHumansJointsLongitudinal StudiesMaleModels, BiologicalMortalityNeural PathwaysNeuronal PlasticityBiomarkersGuanine Nucleotide Exchange FactorsProtein Serine-Threonine KinasesTRIO protein, humanagingjoint modelsLong Life Family StudyMahalanobis distancemortality

Identifiers

PMID32235003
PMCPMC7185144
OpenAlexW3014109350

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.