Evidence map›Paper›PMID 32244373›Full record

ArticleMicroorganisms2020

The Microbiota-Gut-Brain Axis-Heart Shunt Part II: Prosaic Foods and the Brain-Heart Connection in Alzheimer Disease.

Mark Obrenovich, Shams Tabrez, Bushra Siddiqui, Benjamin McCloskey, George Perry

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mark ObrenovichResearch Service, Louis Stokes Cleveland, Department of Veteran's Affairs Medical Center, Cleveland, OH 44106, USA.
Shams TabrezKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Bushra SiddiquiNorth East Ohio College of Medicine, Rootstown, OH 44272, USA.
Benjamin McCloskeyThe Gilgamesh Foundation for Medical Science and Research, Cleveland, OH 44116, USA.
George PerryDepartment of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0002-6547-0172
Cleveland State University · USKing Abdulaziz University · SANortheast Ohio Medical University · USThe University of Texas at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a strong cerebrovascular component to brain aging, Alzheimer disease, and vascular dementia. Foods, common drugs, and the polyphenolic compounds contained in wine modulate health both directly and through the gut microbiota. This observation and novel findings centered on nutrition, biochemistry, and metabolism, as well as the newer insights we gain into the microbiota-gut-brain axis, now lead us to propose a shunt to this classic triad, which involves the heart and cerebrovascular systems. The French paradox and prosaic foods, as they relate to the microbiota-gut-brain axis and neurodegenerative diseases, are discussed in this manuscript, which is the second part of a two-part series of concept papers addressing the notion that the microbiota and host liver metabolism all play roles in brain and heart health.

Indexed as

Alzheimer diseasebraincerebrovascularco-metabolismFrench paradoxheartmicrobiota-gut-brain axisParkinson’s diseasepolyphenolprosaic foodsred winetrimethylamine-N-oxide (TMANO/TMAO)

Identifiers

PMID32244373
PMCPMC7232206
OpenAlexW3015070025

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.