Evidence map›Paper›PMID 32244488›Full record

ReviewMarine drugs2020

Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria.

María Álvarez-Bardón, Yolanda Pérez-Pertejo, César Ordóñez, Daniel Sepúlveda-Crespo, Nestor M Carballeira, Babu L Tekwani, Sankaranarayanan Murugesan, Maria Martinez-Valladares, Carlos García-Estrada, Rosa M Reguera and 1 more

Abstract readReview
In one paragraph

Review in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Phenotypic Analysis of the Anti-Molecules (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Bioprospecting for Anti-Kinetoplastid Drug Discovery fromInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Exploring the genetic progression of MDR1 inCurrent research in microbial sciences · 2024
    Article
  10. In Silico Approach Triterpene Glycoside ofBioMed research international · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

María Álvarez-BardónDepartment of Biomedical Sciences, University of León, 24071 León, Spain.ORCID 0000-0002-0930-0371
Yolanda Pérez-PertejoDepartment of Biomedical Sciences, University of León, 24071 León, Spain.
César OrdóñezDepartment of Biomedical Sciences, University of León, 24071 León, Spain.
Daniel Sepúlveda-CrespoDepartment of Biomedical Sciences, University of León, 24071 León, Spain.ORCID 0000-0002-8053-6045
Nestor M CarballeiraDepartment of Chemistry, University of Puerto Rico, Río Piedras 00925-2537, San Juan, Puerto Rico.
Babu L TekwaniDepartment of Infectious Diseases, Division of Drug Discovery, Southern Research, Birmingham, AL 35205, USA.
Sankaranarayanan MurugesanDepartment of Pharmacy, Birla Institute of Technology and Science, Pilani Campus, Vidya Vihar, Pilani 333031, India.
Maria Martinez-ValladaresDepartment of Animal Health, Instituto de Ganadería de Montaña (CSIC-Universidad de León), 24346 Grulleros, León, Spain.ORCID 0000-0002-3723-1895
Carlos García-EstradaINBIOTEC (Instituto de Biotecnología de León), Avda. Real 1-Parque Científico de León, 24006 León, Spain.
Rosa M RegueraDepartment of Biomedical Sciences, University of León, 24071 León, Spain.
Rafael Balaña-FouceDepartment of Biomedical Sciences, University of León, 24071 León, Spain.ORCID 0000-0003-0418-6116

Funding

Consejería de Educación, Junta de Castilla y León LE020P17Ministerio de Economía y Competitividad AGL2016-79813-C2-1RMinisterio de Economía y Competitividad RYC-2015-18368Ministerio de Economía y Competitividad SAF2017-83575-R
6 · The paper itself

Abstract

Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for those living in poor or developing countries. Almost one-sixth of the world population is at risk of suffering from these diseases and many thousands die because of NTDs, to which we should add the sanitary, labor and social issues that hinder the economic development of these countries. Protozoan-borne diseases are responsible for more than one million deaths every year. Visceral leishmaniasis, Chagas disease or sleeping sickness are among the most lethal NTDs. Despite not being considered an NTD by the World Health Organization (WHO), malaria must be added to this sinister group. Malaria, caused by the apicomplexan parasite

Indexed as

AnimalsAntiprotozoal AgentsAquatic OrganismsBiological ProductsDrug DiscoveryDrug ResistanceEuglenozoa InfectionsHigh-Throughput Screening AssaysHumansMalaria, FalciparumNeglected DiseasesPlasmodium falciparumPlasmodium malariaeTrypanosomatinaAntiprotozoal AgentsBiological Productschloroquine derivativeshigh-throughput screeningmalariamarine pharmacologyneglected tropical diseasesphenotypic screeningtarget-based screeningtrypanosomatids

Identifiers

PMID32244488
PMCPMC7230869

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.