ArticleBMC genomics2020
Genome-wide analysis of Myo-inositol oxygenase gene family in tomato reveals their involvement in ascorbic acid accumulation.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 79 citations in OpenAlex.
- Integrated Physiological, Transcriptomic, and Metabolomic Analyses Reveal the Adaptive Response ofPlants (Basel, Switzerland) · 2026Article
- Regulation of ascorbic acid metabolism in postharvest navel orange fruit during storage by exogenous hydrogen sulfide.Frontiers in nutrition · 2026Article
- Enhancing tomato quality, high sugar content and GABA accumulation, with mutations in ESKs and GAD3 genes.Scientific reports · 2025Article
- Integrated physiological, biochemical and transcriptomic analyses revealed key genes regulating ascorbic acid biosynthesis during sweet potato development.Food chemistry. Molecular sciences · 2025Article
- Overexpression ofInternational journal of molecular sciences · 2025Article
- MsAREB1 enhances combined cold and saline-alkali stress tolerance by promoting ascorbic acid biosynthesis in alfalfa.Plant biotechnology journal · 2025Article
- Transcriptome Analysis Reveals Mechanisms of Stripe Rust Response in Wheat Cultivar Anmai1350.International journal of molecular sciences · 2025Article
- Integrated Analysis of Transcriptomics and Proteomics Provides Insights into the Accumulation Mechanism of Ascorbic Acid inFoods (Basel, Switzerland) · 2025Article
- Identification of Key Enzymes and Genes Modulating L-Ascorbic Acid Metabolism During Fruit Development ofInternational journal of molecular sciences · 2024Article
- NAC61 regulates late- and post-ripening osmotic, oxidative, and biotic stress responses in grapevine.Journal of experimental botany · 2024Article
- Enhanced resistance to heat and fungal infection in transgenic Trichoderma via over-expressing the HSP70 gene.AMB Express · 2024Article
- ETHYLENE-INSENSITIVE 3-LIKE 2 regulates β-carotene and ascorbic acid accumulation in tomatoes during ripening.Plant physiology · 2023Article
- Characterization ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Exogenously Applied Cyclitols and Biosynthesized Silver Nanoparticles Affect the Soluble Carbohydrate Profiles of Wheat (Plants (Basel, Switzerland) · 2023Article
- Plant-herbivore interactions: Experimental demonstration of genetic variability in plant-plant signalling.Evolutionary applications · 2023Article
- Transcriptome comparison analyses in UV-B induced AsA accumulation of Lactuca sativa L.BMC genomics · 2023Article
- Metabolism and Regulation of Ascorbic Acid in Fruits.Plants (Basel, Switzerland) · 2022Review
- Metabolic engineering in food crops to enhance ascorbic acid production: crop biofortification perspectives for human health.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Review
- Advances in Understanding and Harnessing the Molecular Regulatory Mechanisms of Vegetable Quality.Frontiers in plant science · 2022Review
- Gene expression profiling inFrontiers in plant science · 2022Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAscorbic acid (Vitamin C, AsA) is an antioxidant metabolite involved in plant development and environmental stimuli. AsA biosynthesis has been well studied in plants, and MIOX is a critical enzyme in plants AsA biosynthesis pathway. However, Myo-inositol oxygenase (MIOX) gene family members and their involvement in AsA biosynthesis and response to abiotic stress remain unclear.
resultsIn this study, five tomato genes encoding MIOX proteins and possessing MIOX motifs were identified. Structural analysis and distribution mapping showed that 5 MIOX genes contain different intron/exon patterns and unevenly distributed among four chromosomes. Besides, expression analyses indicated the remarkable expression of SlMIOX genes in different plant tissues. Furthermore, transgenic lines were obtained by over-expression of the MIOX4 gene in tomato. The overexpression lines showed a significant increase in total ascorbate in leaves and red fruits compared to control. Expression analysis revealed that increased accumulation of AsA in MIOX4 overexpression lines is possible as a consequence of the multiple genes involved in AsA biosynthesis. Myo inositol (MI) feeding in leaf and fruit implied that the Myo-inositol pathway improved the AsA biosynthesis in leaves and fruits. MIOX4 overexpression lines exhibited a better light response, abiotic stress tolerance, and AsA biosynthesis capacity.
conclusionsThese results showed that MIOX4 transgenic lines contribute to AsA biosynthesis, evident as better light response and improved oxidative stress tolerance. This study provides the first comprehensive analysis of the MIOX gene family and their involvement in ascorbate biosynthesis in tomato.
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