ArticleOxidative medicine and cellular longevity2020
Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway.
Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 38 citations in OpenAlex.
- Synergistic antidiabetic efficacy of dorzolamide and metformin: HPTLC quantification and biological evaluation.Scientific reports · 2026Article
- Characteristics of Polyphenols of Black Hulless Barley Bran and Its Anti-Diabetic Activity.Foods (Basel, Switzerland) · 2025Article
- Hypoglycemic effects of Caesalpinia bonduc (L). Roxb leaf extract in streptozotocin-induced diabetic rats.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Phenolics Extracted fromMolecules (Basel, Switzerland) · 2023Article
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- Pharmacological Studies on the Antidiabetic, Antioxidant, and Antimicrobial Efficacies ofJournal of diabetes research · 2023Article
- Combinatory Effect and Modes of Action of Chrysin and Bone Marrow-Derived Mesenchymal Stem Cells on Streptozotocin/Nicotinamide-Induced Diabetic Rats.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Polysaccharide-Rich Red Algae (Molecules (Basel, Switzerland) · 2022Article
- Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans.Biomedicines · 2021Review
- Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challenges.Endocrine connections · 2021Review
- High anti-inflammatory and antidiabetic activities ofJournal of diabetes and metabolic disorders · 2021Article
- (-)-Leucophyllone, a Tirucallane Triterpenoid fromPlants (Basel, Switzerland) · 2021Article
- Metabolomic profiling to reveal the therapeutic potency ofRSC advances · 2021Article
- Mechanisms Underlying the Antidiabetic Activities of Polyphenolic Compounds: A Review.Frontiers in pharmacology · 2021Review
- A 90-Day Oral Toxicity Study of an Ethanolic Root Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3.Experimental biology and medicine (Maywood, N.J.) · 2020Article
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9 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Caesalpinia bonduc has been used in herbal medicines for the treatment of a wide range of diseases from decades. The present study has explored the remedial potential and underlying mechanism of polyphenol extract of Caesalpinia bonduc in alloxanized diabetic rats. HPLC/MS analysis confirmed the presence of phenolics in considerable concentrations in Caesalpinia bonduc extract. Administration of different doses (250 and 500 mg/kg) of CPP extract to hyperglycemic rats for 8 weeks restored blood and serum glucose, insulin, glycosylated hemoglobin, leptin, amylin, and carbohydrate metabolizing enzymes level towards normal compared to alloxanized diabetic group. The effect of CPP extract on various genes such as Pdx-1, Ins-1, ngn-3, GLUT-4, and IRS-1 in insulin signaling pathway and Traf-4, Traf-6, and Mapk-8 in MAPK downstream JNK cascade was examined through qRT-PCR to access the core molecular mechanism involved in CPP-induced recovery of diabetes. Results have revealed that CPP extract reduced oxidative stress in pancreatic
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