SynthesisJournal of diabetes research2020
Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis.
Synthesis in Journal of diabetes research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Famine Exposure during Early Life and Risk of Cancer in Adulthood: A Systematic Review and Meta-Analysis.The journal of nutrition, health & aging · 2023Pooled it
- Early-Life Exposure to the Chinese Famine of 1959-1961 and Type 2 Diabetes in Adulthood: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Severe malnutrition or famine exposure in childhood and cardiometabolic non-communicable disease later in life: a systematic review.BMJ global health · 2021Pooled it
- Childhood famine exposure and the risk of gastrointestinal diseases in old individuals: a retrospective cohort analysis using the CHARLS database.BMC public health · 2026Article
- Early-Life famine exposure and the risk of depression and anxiety in adulthood: evidence from the China Multi-Ethnic Cohort (CMEC).BMC psychiatry · 2025Article
- Fetal programming and lactation: modulating gene expression in response to undernutrition during intrauterine life.Pediatric research · 2024Article
- Famine exposure in early life increases risk of cataracts in elderly stage.Frontiers in nutrition · 2024Article
- Separate and combined effects of famine exposure and menarche age on metabolic syndrome among the elderly: a cross-sectional study in China.BMC women's health · 2023Article
- Article
- Effects of fetal famine exposure on the cardiovascular disease risk in the metabolic syndrome individuals.Diabetology & metabolic syndrome · 2022Article
- Association between early life famine exposure and risk of metabolic syndrome in later life.Journal of diabetes · 2022Article
- Editorial: Intrauterine nutrition and adult metabolism.Frontiers in nutrition · 2022Article
- Sex Differences at Early Old Stage in Glycolipid Metabolism and Fatty Liver in Offspring Prenatally Exposed to Chinese Great Famine.Frontiers in nutrition · 2022Article
- Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood.International journal of environmental research and public health · 2020Article
- Prevalence and Correlation of Metabolic Syndrome: A Cross-Sectional Study of Nearly 10 Million Multi-Ethnic Chinese Adults.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging studies have explored the association between the famine exposure during early life and the risk of the metabolic syndrome, and the results remain controversial. This meta-analysis was performed to summarize the famine effects on the prevalence of metabolic syndrome (MetS) in adulthood.
resultsThe analyses included 39 studies from 10 articles with a total of 81504 participants. Fourteen studies from 10 articles for fetal famine exposure, 20 studies from 7 articles for childhood famine exposure, and 5 studies from 3 articles for adolescence/adult famine exposure were included in this meta-analysis. Compared with a nonexposed group, famine exposure significantly increased the risk of MetS for early life famine exposure (OR = 1.27, 95% CI: 1.18-1.38), fetal famine exposure (OR = 1.27, 95% CI: 1.14-1.43), and childhood famine exposure (OR = 1.29, 95% CI: 1.16-1.44). Subgroup analyses showed that the result was consistent regardless of the study designs, definitions of MetS, and causes of famine, with or without adjustment for age, smoking, drinking, and physical activity.
conclusionsThis meta-analysis suggests that exposure to famine during early life may increase the risk of MetS in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.