ReviewCirculation research2020
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.
2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph
Review in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,177 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,177citing papers in PubMed, 3 pooled it
41.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sildenafil for Treating Patients With COVID-19 and Perfusion Mismatch: A Pilot Randomised Trial
Effect of the Combination of Dipeptidyl Peptidase-4 Inhibitor (DPP4i) and Insulin in Comparison to Insulin on Metabolic Control and Prognosis in Hospitalized Patients With COVID-19
Who cites it
1,177 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,893 citations in OpenAlex.
- Mortality Assessment in Patients with Cardiovascular Disease and COVID-19: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- COVID-19 in comorbid chronic diseased patients, pregnant and lactating women: pathophysiology, available drug treatment, and the most suitable protocol regimen in each group.Inflammopharmacology · 2025Pooled it
- COVID-19 induced type 1 diabetes: A systematic review of case reports and series.The Journal of international medical research · 2023Pooled it
- Disulfide bond formation between Cys22 and Cys44 in SARS-CoV-2 main protease.Bioorganic & medicinal chemistry letters · 2026Article
- Effect of COVID-19 on Retinal and Choroidal Microvasculature in the Pediatric Population: A Literature Review.Medicina (Kaunas, Lithuania) · 2026Review
- Article
- Neuroprotective Potential of Peptide KSVSPKFLTG fromAntioxidants (Basel, Switzerland) · 2026Article
- The Effect of COVID-19 Vaccines on Chronic Inflammatory Remodeling in NSTEMI Patients: A Galectin-3-Based Single-Center Study.Journal of clinical medicine · 2026Article
- Xenosialylation as immunological chimerism: a host-centered unifying model for viral and post-vaccination immune complications.European cytokine network · 2026Review
- Pathogen-Specific Regulation of Renin-Angiotensin System Genes in Epithelial Cells: A Comparative Study of SARS-CoV-2 Spike Protein N-Terminal Domain Fragment and Bacterial Lipopolysaccharide.Pathogens (Basel, Switzerland) · 2026Article
- COVID-19 and cardiovascular outcomes in patients with pre-existing hypertension.Journal of human hypertension · 2026Review
- Therapeutic effect of N-acetylcysteine in severe or critical coronavirus disease 2019 pneumonia: A retrospective cohort study.The Journal of international medical research · 2026Article
- SARS-CoV-2 infection reduces the number of spermatogonial stem cells and dysregulates the transcriptional landscape of the human testis.Research square · 2026Article
- COVID-19 Prophylactic Effect of Bromhexine Hydrochloride.Immunity, inflammation and disease · 2026Article
- DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction.Journal of nanobiotechnology · 2026Article
- Angiotensin‑converting enzyme 2 as an immune and prognostic biomarker in colorectal cancer.Scientific reports · 2026Article
- Novel aspects of the renin-angiotensin-aldosterone system in septic shock.Current opinion in physiology · 2026Article
- Decreased Plasma Concentration of Hydrogen Sulfide in Hospitalized COVID-19 Patients: A Novel Determinant of Mortality?Antioxidants (Basel, Switzerland) · 2026Article
- High-flow nasal-cannula oxygen therapy in intensive-care-unit patients: a prospective multicenter observational cohort study (OHE-REA).Scientific reports · 2026Observational
- Coronary artery calcification is associated with reduced survival in mechanically ventilated COVID-19 patients in the MaastrICCht cohort.Scientific reports · 2026Article
1,117 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors at 5 institutions in 4 countries.
Mahmoud Gheblawi *From the Department of Physiology (M.G., A.V., G.Y.O.).
Kaiming Wang *Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada (K.W., Q.N., G.Y.O.).
Anissa ViveirosFrom the Department of Physiology (M.G., A.V., G.Y.O.).
Quynh NguyenDivision of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada (K.W., Q.N., G.Y.O.).
Jiu-Chang ZhongHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, China (J.-C.Z.).
Anthony J TurnerSchool of Biomedical Sciences, University of Leeds, United Kingdom (A.J.T.).
Mohan K RaizadaDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville (M.K.R.).
Maria B GrantDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (M.B.G.).
Gavin Y OuditFrom the Department of Physiology (M.G., A.V., G.Y.O.).
University of Alberta · CACapital Medical University · CNUniversity of Alabama at Birmingham · USUniversity of Florida · USUniversity of Leeds · GB
Funding
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5MVisual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9MAngiotensin-Converting Enzyme2 in Vascular Endothelial FunctionR01HL102033 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K. · 2010 to 2019
$4.3MVascular Reparative Mechanism by ACE2/Ang-(1-7)in DiabetesR01HL110170 · NHLBI · UNIVERSITY OF FLORIDA · PI GRANT, MARIA BARTOLOMEO · 2011 to 2015
$2.2MSomatostatin blockade of CNS autonomic hyperactivity for treatment of diabetic retinopathyR01EY028037 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, FRAZIER, CHARLES J · 2017 to 2020
$1.9MACE2 Modulates the Bone Marrow- Gut Axis in Diabetic RetinopathyR01EY028858 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, GRANT, MARIA BARTOLOMEO · 2018 to 2021
$1.6MCanadian Institutes of HealthNEI NIH HHS P30 EY003039NEI NIH HHS R01 EY028037NEI NIH HHS R01 EY028858NHLBI NIH HHS R01 HL102033NHLBI NIH HHS R01 HL110170NIDDK NIH HHS P30 DK079626
Abstract
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-CoV-2 receptor.
Indexed as
Cardiovascular DiseasesCoronavirus InfectionsPandemicsPneumonia, ViralADAM17 ProteinAngiotensin-Converting Enzyme 2AnimalsBetacoronavirusCOVID-19COVID-19 Drug TreatmentDiabetes ComplicationsHumansMolecular Targeted TherapyPeptidyl-Dipeptidase AReceptors, VirusRenin-Angiotensin SystemACE2 protein, humanADAM17 ProteinAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase AReceptors, Viruscardiovascular diseasescoronavirusdysbiosisheart failurerenin-angiotensin system
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT04489446ClinicalTrials.gov
NCT04542213ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.