Evidence map›Paper›PMID 32265294›Full record

ArticleMolecular & cellular proteomics : MCP2020

Characterization of Signaling Pathways Associated with Pancreatic β-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in

Taewook Kang, Brandon B Boland, Pia Jensen, Cristina Alarcon, Arkadiusz Nawrocki, Joseph S Grimsby, Christopher J Rhodes, Martin R Larsen

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  5. Stem Cell-Derived Islets for Type 2 Diabetes.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Taewook KangProtein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark; The Danish Diabetes Academy, Odense, Denmark.
Brandon B BolandThe Kovler Diabetes Center, Department of Medicine Section of Endocrinology, Diabetes & Metabolism, University of Chicago, Chicago, Illinois 60637; Cardiovascular, Renal and Metabolic Disease, BioPharmaceuticals Research and Development, AstraZeneca Gaithersburg, Maryland 20878.
Pia JensenProtein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark.
Cristina AlarconThe Kovler Diabetes Center, Department of Medicine Section of Endocrinology, Diabetes & Metabolism, University of Chicago, Chicago, Illinois 60637.
Arkadiusz NawrockiProtein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark.
Joseph S GrimsbyCardiovascular, Renal and Metabolic Disease, BioPharmaceuticals Research and Development, AstraZeneca Gaithersburg, Maryland 20878.
Christopher J RhodesThe Kovler Diabetes Center, Department of Medicine Section of Endocrinology, Diabetes & Metabolism, University of Chicago, Chicago, Illinois 60637; Cardiovascular, Renal and Metabolic Disease, BioPharmaceuticals Research and Development, AstraZeneca Gaithersburg, Maryland 20878.
Martin R LarsenProtein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark. Electronic address: mrl@bmb.sdu.dk.
University of Southern Denmark · DKUniversity of Chicago · USAstraZeneca (United States) · US

Funding

METABOLIC CONTROL PROINSULIN BIOSYNTHESIS TRANSLATIONR01DK050610 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI RHODES, CHRISTOPHER J · 1996 to 2014
$5.1M
NIDDK NIH HHS R01 DK050610
6 · The paper itself

Abstract

The onset of obesity-linked type 2 diabetes (T2D) is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to obesity. However, in a commonly used model of T2D, the

Indexed as

AnimalsBlood GlucoseDiabetes Mellitus, Type 2Disease Models, AnimalFocal AdhesionsGene OntologyGlucoseHyperglycemiaInsulinInsulin-Secreting CellsInsulin SecretionMAP Kinase Signaling SystemMiceMice, Inbred C57BLObesityPhosphoproteinsBlood GlucoseGlucoseInsulinPhosphoproteinsProinsulinProteomeSialic Acidsbeta-granule biogenesisDiabetesglycoprotein pathwaysglycoproteomicsinsulin resistanceinsulin secretory pathwayobesityphosphoproteomeproinsulin biosynthesisprotein degradationprotein foldingprotein-protein interactionsprotein synthesissignal transductionunfolded protein response

Identifiers

PMID32265294
PMCPMC7261816
OpenAlexW3014646407

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.