Evidence map›Paper›PMID 32268515›Full record

ArticleViruses2020

In Silico Discovery of Candidate Drugs against Covid-19.

Claudia Cava, Gloria Bertoli, Isabella Castiglioni

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 3 pooled it
26.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 208 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Landscape of Molecular Crosstalk Perturbation between Lung Cancer and COVID-19.International journal of environmental research and public health · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  18. Review
  19. DrugWAS: Drug-wide Association Studies for COVID-19 Drug Repurposing.Clinical pharmacology and therapeutics · 2021
    Article
  20. Inhibition of the RNA-dependent RNA Polymerase of the SARS-CoV-2 by Short Peptide Inhibitors.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2021
    Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Claudia CavaInstitute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Via F.Cervi 93, 20090 Segrate-Milan, Milan, Italy.ORCID 0000-0002-5540-4104
Gloria BertoliInstitute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Via F.Cervi 93, 20090 Segrate-Milan, Milan, Italy.ORCID 0000-0002-5901-4269
Isabella CastiglioniDepartment of Physics "Giuseppe Occhialini", University of Milan-Bicocca Piazza dell'Ateneo Nuovo, 1 - 20126, Milan, Italy.
Institute of Molecular Bioimaging and Physiology · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies reported that Angiotensin converting enzyme 2 (ACE2) is the main cell receptor of SARS-CoV and SARS-CoV-2. It plays a key role in the access of the virus into the cell to produce the final infection. In the present study we investigated in silico the basic mechanism of

Indexed as

Antiviral AgentsDrug DiscoveryAngiotensin-Converting Enzyme 2Anti-Inflammatory AgentsBetacoronavirusComputational BiologyComputer SimulationCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDatabases, GeneticGene Expression ProfilingGene Regulatory NetworksHumansLungPandemicsACE2 protein, humanAngiotensin-Converting Enzyme 2Anti-Inflammatory AgentsAntiviral AgentsPeptidyl-Dipeptidase AReceptors, CoronavirusReceptors, Virusbioinformaticscovid-19drugsgene network

Identifiers

PMID32268515
PMCPMC7232366
OpenAlexW3014705243

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.