Evidence mapPaperPMID 32273845Full record

ArticleFrontiers in pharmacology2020

Prospective Risk Assessment of Medicine Shortages in Europe and Israel: Findings and Implications.

Nenad Miljković, Brian Godman, Milena Kovačević, Piera Polidori, Leonidas Tzimis, Torsten Hoppe-Tichy, Marika Saar, Ioan Antofie, Laszlo Horvath, Thomas De Rijdt and 31 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Drug shortages in Israel, revisited: a bitter pill to swallow.Israel journal of health policy research · 2024
    Article
  3. Article
  4. Medicine shortages in France: a 6-year retrospective study in a university medical centre.European journal of hospital pharmacy : science and practice · 2023
    Article
  5. Access to medicines.European journal of hospital pharmacy : science and practice · 2023
    Article
  6. Drug shortages in China: a cross-sectional study.BMC health services research · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Results of EAHP's 2019 Medicines Shortages Survey.European journal of hospital pharmacy : science and practice · 2020
    Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Nenad MiljkovićInstitute of Orthopaedic Surgery "Banjica", University of Belgrade, Belgrade, Serbia.
Brian GodmanDivision of Clinical Pharmacology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Milena KovačevićDepartment of Pharmacokinetics and Clinical Pharmacy, University of Belgrade, Belgrade, Serbia.
Piera PolidoriDepartment of Clinical Pharmacy, IRCCS, ISMETT, Palermo, Italy.
Leonidas TzimisHospital Pharmacy Department, Chania General Hospital, Crete, Greece.
Torsten Hoppe-TichyPharmacy Department, Heidelberg University Hospital, Heidelberg, Germany.
Marika SaarPharmacy Department, Tartu University Hospital, Tartu, Estonia.
Ioan AntofieHospital Pharmacy Department, Spitalul Clinic C. F. Cluj-Napoca, Cluj-Napoca, Romania.
Laszlo HorvathDepartment of Pharmaceutical Surveillance and Economics, University of Debrecen, Debrecen, Hungary.
Thomas De RijdtPharmacy Department, University Hospitals Leuven, UZ Herestraat, Leuven, Belgium.
Róbert György VidaDepartment of Pharmaceutics and Central Clinical Pharmacy, Faculty of Pharmacy, University of Pécs, Pécs, Hungary.
Elena KkolouHospital Pharmacy Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
David PreeceLeeds Medicines Advisory Service, The Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, United Kingdom.
Biljana TubićSector for Medicinal Products, Agency for Medicines and Medical Devices of Bosnia and Herzegovina, Banja Luka, Bosnia and Herzegovina.
Joan PeppardHospital Pharmacy Department, Midland Regional Hospital, Tullamore, Ireland.
Alicia MartinezServicio de Farmacia, Hospital Universitario Infanta Sofía, Madrid, Spain.
Cristina Garcia YuberoServicio de Farmacia, Hospital Universitario Infanta Sofía, Madrid, Spain.
Ratiba HaddadHospital Pharmacy Department, Hôpital Antoine Béclère, Clamart, France.
Dragana RajinacHospital Pharmacy Department, Clinical Centre of Serbia, Belgrade, Serbia.
Pavle ZelićInternational Cooperation and Public Relation Department, Medicines and Medical Device Agency of Serbia, Belgrade, Serbia.
Helena JenzerHealth Division, Berner Fachhochschule Health Professions Ernährung und Diätetik, Bern, Switzerland.
Franci TartarDepartment of Hospital Pharmacy, General Hospital Celje, Celje, Slovenia.
Gunda GitlerHospital Pharmacy Department, Apotheke der Barmherzigen Brüdere. U., Linz, Austria.
Martina JeskePharmacy Department, University Clinic-State Hospital of Innsbruck, Innsbruck, Austria.
Michal DavidescuFaculty of Social Sciences, The Graduate School of Business Administration, Tel Aviv, Israel.
Guillaume BeraudMédecine Interne et Maladies Infectieuses, CHU de Poitiers, Poitiers, France.
Darija Kuruc-PojeHospital Pharmacy Department, General hospital "dr. Tomislav Bardek", Koprivnica, Croatia.
Kristine Sakstrup HaagNomeco-Hospital&Customer Service, Nomeco Commercial Affairs, Copenhagen, Denmark.
Hanne FischerStrategic Procurement and Supply of Pharmaceuticals, Amgros I/S, Copenhagen, Denmark.
Inese SviestinaHospital Pharmacy Department, Children's Clinical University Hospital, Riga, Latvia.
Gordana LjubojevićDepartment of Physical Medicine and Rehabilitation "Dr Miroslav Zotović", Banja Luka, Bosnia and Herzegovina.
Anne MarkestadNational Center for Medicine Shortages in Hospitals, Oslo universitetssykehus HF, Nydalen, Norway.
Vesna Vujić-AleksićCertification Department, The Republic of Srpska Agency for Certification, Accreditation and Quality Improvement in Health Care, Banja Luka, Bosnia and Herzegovina.
Lana NežićDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina.
Anica CrkvenčićCommunity Pharmacy Department, Pharmacy "Biljana", Banja Luka, Bosnia and Herzegovina.
Johanna LinnolahtiDivision DEFO, Finnish Medicines Agency, Helsinki, Finland.
Bogdan AšaninDepartment of Surgery, Department of Medical Ethics, Medical Faculty of the University of Montenegro, Podgorica, Montenegro.
Nataša Duborija-KovačevićDepartment of Pharmacology and Clinical Pharmacology, Medical Faculty of the University of Montenegro, Podgorica, Montenegro.
Tomasz BochenekDepartment of Drug Management, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
Isabelle HuysDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Branislava MiljkovićDepartment of Pharmacokinetics and Clinical Pharmacy, University of Belgrade, Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhile medicine shortages are complex, their mitigation is more of a challenge. Prospective risk assessment as a means to mitigate possible shortages, has yet to be applied equally across healthcare settings. The aims of this study have been to: 1) gain insight into risk-prevention against possible medicine shortages among healthcare experts; 2) review existing strategies for minimizing patient-health risks through applied risk assessment; and 3) learn from experiences related to application in practice. METHODOLOGY: A semi-structured questionnaire focusing on medicine shortages was distributed electronically to members of the European Cooperation in Science and Technology (COST) Action 15105 (28 member countries) and to hospital pharmacists of the European Association of Hospital Pharmacists (EAHP) (including associated healthcare professionals). Their answers were subjected to both qualitative and quantitative analysis (Microsoft Office Excel 2010 and IBM SPSS Statistics

resultsThe participants (61.7%) are aware of the use of risk assessment procedures as a coping strategy for medicine shortages, and named the particular risk assessment procedure they are familiar with failure mode and effect analysis (FMEA) (26.4%), root cause analysis (RCA) (23.5%), the healthcare FMEA (HFMEA) (14.7%), and the hazard analysis and critical control point (HACCP) (14.7%). Only 29.4% report risk assessment as integrated into mitigation strategy protocols. Risk assessment is typically conducted within multidisciplinary teams (35.3%). Whereas 14.7% participants were aware of legislation stipulating risk assessment implementation in shortages, 88.2% claimed not to have reported their findings to their respective official institutions. 85.3% consider risk assessment a useful mitigation strategy.

conclusionThe study indicates a lack of systematically organized tools used to prospectively analyze clinical as well as operationalized risk stemming from medicine shortages in healthcare. There is also a lack of legal instruments and sufficient data confirming the necessity and usefulness of risk assessment in mitigating medicine shortages in Europe.

Indexed as

Europemedicine shortagemitigation strategyrisk assessmentsubstitution

Identifiers

PMID32273845
PMCPMC7114887

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.