Evidence map›Paper›PMID 32286894›Full record

Trial reportJournal of medicinal food2020

Effects of Cacao By-Products and a Modest Weight Loss Intervention on the Concentration of Serum Triglycerides in Overweight Subjects: Proof of Concept.

Perla León-Flores, Nayelli Nájera, Elizabeth Pérez, Blanca Pardo, Fiacro Jimenez, Dylan Diaz-Chiguer, Francisco Villarreal, Isabel Hidalgo, Guillermo Ceballos, Eduardo Meaney

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of medicinal food, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Dietary supplements for obesity.Journal of preventive medicine and hygiene · 2022
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Perla León-FloresIntegral Caardiometabolic Research Laboratory, Research and Posgraduate Studies Section, School of Medicine, National Polytechnique Institute, Mexico City, Mexico.
Nayelli NájeraIntegral Caardiometabolic Research Laboratory, Research and Posgraduate Studies Section, School of Medicine, National Polytechnique Institute, Mexico City, Mexico.
Elizabeth PérezUnit of Metabolism and Nutritional Support, Hospital Juarez, Mexico City, Mexico.
Blanca PardoUnit of Metabolism and Nutritional Support, Hospital Juarez, Mexico City, Mexico.
Fiacro JimenezHealth Norms Direction, ISSSTE, Mexico City, Mexico.
Dylan Diaz-ChiguerHealth Norms Direction, ISSSTE, Mexico City, Mexico.
Francisco VillarrealSchool of Medicine, University of California, San Diego, California, USA.
Isabel HidalgoIntegral Caardiometabolic Research Laboratory, Research and Posgraduate Studies Section, School of Medicine, National Polytechnique Institute, Mexico City, Mexico.
Guillermo CeballosIntegral Caardiometabolic Research Laboratory, Research and Posgraduate Studies Section, School of Medicine, National Polytechnique Institute, Mexico City, Mexico.
Eduardo MeaneyIntegral Caardiometabolic Research Laboratory, Research and Posgraduate Studies Section, School of Medicine, National Polytechnique Institute, Mexico City, Mexico.
National Institute of Genomic Medicine · MXHospital Juárez de México · MXInstitute for Social Security and Services for State Workers · MXUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic approaches to decrease serum triglyceride (TG) concentrations are not successful mainly due to poor adherence or adverse effects of therapies. In consequence, the search for new low-cost and safer therapeutic alternatives is mandatory. Dark chocolate and cacao have shown promising results improving lipid profiles. Recently, using cacao by-products to reduce elevated cardiometabolic risk markers in an animal model of obesity induced by a high-fat diet and fructose, we showed that TGs, low-density lipoprotein cholesterol, and the TG/high-density lipoprotein (HDL) ratio decreased, suggesting that cacao by-products improved the metabolic function of obese animals. Based on these results, as a proof of concept, a blinded placebo-controlled study was implemented to explore the effects of cacao by-products on anthropometric and biochemical variables in a group of overweight subjects participating in a program composed of reduced-calorie-diet counseling plus a simple aerobic exercise plan. The results showed that counseling induced weight and abdominal circumference reductions in both groups. TGs did not change in the control group; however, TG decreased significantly by 54.9 mg/dL (27.9%) in the experimental group. The TG/HDL cholesterol ratio changed markedly (1.5) in the experimental group. The results reported suggest the use of cacao by-products as an alternative for the treatment of hypertriglyceridemia.

Indexed as

Weight LossAdultAnimalsCacaoCholesterol, HDLHumansMiddle AgedObesityOverweightProof of Concept StudyTriglyceridesCholesterol, HDLTriglyceridescacao by-productshypertriglyceridemiaobesity

Identifiers

PMID32286894
PMCPMC7370978
OpenAlexW3015450623

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.